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conferenceseries.com
Volume 7, Issue 7 (Suppl) J Gastrointest Dig Syst
ISSN: 2161-069X JGDS, an open access journal Gastroenterologists 2017
December 14-15, 2017
December 14-15, 2017 Dubai, UAE
11th World
Gastroenterologists Summit
Effect of chronic liver disease severity and etiology on lipid profiles: An analytical study
Thinakarmani1, Venkateswaran A R1, Bharat Narasimhan2, Ratnakar Kini 1, Kani Sheikh1, Prem Kumar1, Rajkumar Solomon1, Malar Vizhi1, Thangavelu
Pugazhendhi1, Mohammed Ali1, Sibithooran1, Radhakrishnan1, Mohammed Noufal1
1Institute of Medical Gastroenterology, Madras Medical College, India
2Department of Internal Medicine, KMC Mangalore, Manipal University, India
Background & Aims: The liver is integral to lipid metabolism and a compromise in its function leads to perturbations in these
pathways. In this study, we hope to determine the correlation between CLD severity and its effect on lipid parameters. We also
look at the etiology specific effects on lipid levels.
Materials & Methods: This is a retrospective cross-sectional analysis of 250 patients with cirrhosis compared to 250 healthy
age and sex matched controls. Severity assessment of CLD using MELD and Child-Pugh scores was performed and etiological
details collected. A questionnaire was used to obtain patient demographic details and lastly a fasting lipid profile (Total LDL,
HDL, cholesterol, triglycerides and VLDL) was obtained.
Results: All components of the lipid profile declined linearly with increasing severity of CLD as determined by MELD and
Child-Pugh scores. Lipid levels were clearly lower in CLD patients as compared to healthy controls. Interestingly, preliminary
analysis indicated that CLD of different etiologies had differential effects on Lipid profiles-this aspect is under further analysis.
Conclusion: All components of the lipid profile were definitely lower inCLDpatients as compared to controls and demonstrated
an inverse correlation with increasing severity. The utilization of this parameter as a prognosticating aid requires further study.
Additionally, preliminary analysis indicates that various CLD etiologies appear to have specific effects on the lipid profile-a
finding under further analysis.
Biography
Thinakar Mani has completed his MBBS from Pondicherry University and MD Internal Medicine from Manipal University. Currently, he is working as a Senior
Resident at Institute of Medical Gastroenterology at Madras Medical College, Tamil Nadu, India. He has presented many papers at national conferences all around
India.
Thinakar Mani ., J Gastrointest Dig Syst 2017, 7:7 (Suppl)
DOI: 10.4172/2161-069X-C1-061