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Gastro 2016
August 11-12, 2016
Volume 6, Issue 4(Suppl) J Gastrointest Dig Syst 2016
ISSN:2161-069X JGDS, an open access journal
conferenceseries .com
August 11-12, 2016 Birmingham, UK
6th Global Gastroenterologists Meeting
Demographic profile and clinical presentation of ulcerative colitis in Trimurti hospital from
2007 to 2014
Patel Parag G, Chikhaliya Devraj P, Patel Rupal P and Mehta Kajri V
Trimurti Hospital,Gujrat, India
Backround: There is paucity of clinical and demographic information of ulcerative colitis (UC) in rural area of Gujarat.
Objective: To provide clinical and demographic data of UC patients.
Methods: A review was performed in all cases of ulcerative colitis patients in the hospitals from 2007-2014 by retrieval from
medical record department. The diagnosis of UC was based on a combination of clinical, endoscopic and histological findings
consistent with UC. This study focused on food habits which included self identified food triggers and tobacco chewing. Along
with this extraintestinal manifestation were also taken into account. As the duration of study was quite long and data were
obtained by primary questionnaire and follow up. Patients were asked to come to hospital for filling up a questionnaire which
included their current disease condition tobacco chewing habits, smoking history food habits, presumed food triggers analysis
was performed using the Microsoft Excel and Graphpad prism.
Results: A total of 47 patients with UC consulted over the 80 years study period (2007-2014). The mean annual incidence of
UC from 2007-2014 was 17.9 new cases: 100,000 new consults per year. An increase in the mean annual incidence from 9.9 in
2007-2010 to 25.9 in 2011-2014 was noted. 29.8% patients were chronic regular tobacco chewer, 2.1% were regular smokers
and 2.1% patient consumed alcohol regularly. There were 17% patients with family history of UC. Astonishing fact is that
none of the patient required surgical intervention and their symptoms are usually controlled by medicines therapy. None of
the patients had gut obstruction, massive intestinal bleed or toxic megacolon. Mean ESR compared for both the groups was
statistically significant.Weight loss and anemia were one of the key features of UC patients. Extraintestinal manifestation: 8.6%
had episcleritis, 23.4% patients had mouth ulcers, 2.1% patients had erythema nodusum and 17% (8) patients had complain
of hairfall and itching. 31.9% patients had pain while defecation and could not sit longer, who were later diagnosed with
sacroilitis. None of the patient had colingitis.
Conclusion: The incidence of UC in our study is higher than Indian and other Asian country estimates but our rates may
be an overestimation of the true regional incidence since our hospital and associated centers are referral centers. Clinical
presentation is similar to neighboring state and countries except for higher appearance of extraintestinal symptoms and no
surgical intervention. Extensive research is required to understand food habits, tobacco chewing and reason or pattern of high
incidence of disease in this region.
Nucleic acid polymers: Antiviral mechanisms and application in the treatment of chronic HBV and
HBV/HDV infection
Andrew Vaillant
Replicor Inc., Canada
Nucleic acid polymers (NAPs) are a newly emerging antiviral technology for the treatment of chronic HBV infection and
HBV / HDV co-infection. NAPs have the unique ability to clear HBsAg from the blood of human patients, a critical
step in achieving a functional cure in HBV and HBV / HDV infection. Current mechanistic data underlying the basis for this
unique antiviral effect of NAPs as well as updated clinical data from trials using NAP-based combination therapy in patients
with chronic HBV infection and HBV / HDV co-infection will be presented.
J Gastrointest Dig Syst 2016, 6:4(Suppl)