gastroenterologist-2016_posters-accepted-abstracts

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Gastro 2016

August 11-12, 2016

Volume 6, Issue 4(Suppl)

J Gastrointest Dig Syst 2016

ISSN:2161-069X JGDS, an open access journal

conferenceseries

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August 11-12, 2016 Birmingham, UK

Global Gastroenterologists Meeting

Phytobezoars removal with a simple and cost-effective method: Report of 97 cases

Kieu Van Tuan

Bach Mai National Hospital, Vietnam

hytobezoar (PBZ) is mainly composed of fibred food, commonly formed and found in stomach and can be treated with

various methods. In low-resource settings such as Vietnam, the choice of treatment is strongly depended on its cost, efficacy

and availability. Our retrospective study was on 97 patients with PBZ by endoscopic fragment with “modified snare” from

2013 to March 2016 at Bach Mai National Hospital. The instrument that we created to cut the masses dominates the existing

trademark ones with adjustable loop diameter and low cost, moreover it is simple and easy to use. It includes a thin metal string

and a small flexible plastic tube going through working channel. Each patient has a profile containing relevant data. After the

mass removal, patients were re-checked by endoscopy in one day and followed-up in one week. In the study, female accounted

for 59%. PBZ locations found were stomach (74%), duodenum (21%) and jejunum (5%); masses in the two later positions

caused obstruction; mean (SD) dimensions of the conglomeration were 4.6 (1.6) x 3.9 (1.2) x 3.3 (1.2) cm. The successful cases

with one and two/three endoscopic sessions accounted for 96% and 4% respectively. Mean cost of the “modified snare” for

each patient is $2 (1-5). Average time for each session was 30 (15-60) minutes. There were two complicated cases including one

jejunum obstruction due to the fragged masses and one gastric mucosal incision. To conclude, this method is safe and cost-

effective for PBZ elimination.

The role of the novel alarmin IL33 signaling pathway in ulcerative colitis

Marcela Hermoso R

University of Chile, Chile

T2/IL33 signaling pathway has been related to many inflammatory disorders as well as inflammatory bowel disease (IBD).

IL-33, a member of the IL-1 family, is expressed in endothelial and epithelial cells and regulates gene transcription upon its

nuclear translocation. IL-33 is released during necrosis episodes and its precursor is enzymatically processed to promote an

inflammatory response as a damage-associated molecular pattern or alarmin. The IL-33 receptor ST2, encoded by IL1RL1, is

expressed as both a membrane-anchored receptor (ST2L) activated by IL-33 and as a soluble variant (sST2) that behaves as a

decoy receptor in inflammatory conditions and we proposed as a prognostic disease biomarker. We characterized the IL33/ST2

system in mucosa from IBD patients and the effect of clinical course and therapy on sST2 content and cellular distribution as

predictive markers of response to treatment, disease activity and outcome. Additional findings demonstrate the molecular and

cellular mechanisms that regulate mucosa inflammation. This conference will propose cutting-edge biomedical data on recent

advances in the role of ST2 in IBD.

J Gastrointest Dig Syst 2016, 6:4(Suppl)