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Volume 09 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X Gastro Congress 2019
July 08-09, 2019
July 08-09, 2019 | Zurich, Switzerland
14th Euro-Global Gastroenterology Conference
The effect of vitamin D supplementations on TNF-Α, serumHs-CRPand NF-κB in patients with ulcerative
colitis: A randomized, double-blind, placebo-controlled pilot study
Azita Hekmatdoost1 , Sara Karimi1 , Sanam Tabataba-vakili1, Nasser Ebrahimi-Daryani 2, Zahra Yari1, Foroogh Alborzi4 and Mehdi Hedayati3
1Shahid Beheshti University of Medical Sciences, Iran
2Digestive Disease Research Institute, Iran
3Shahid Beheshti University of Medical Sciences, Iran
4Tehran University of Medical Sciences, Iran
Background & Objective: Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative
colitis (UC) is an immune-mediated chronic intestinal disorder with an unknown etiology. The overexpression
of proinflammatory factors such as proinflammatory cytokines is believed to have pivotal role in development of
UC. Among them tumor necrosis factor alpha (TNF-α) is identified as a key cytokine. Also it has indicated that
the levels of expression of NF-κB reflect development and progression of UC. It has no cure until now and the
purposes of treatments are to alleviate signs, lengthening remission and improvement in quality of life in these
patients. Different mechanisms for the effects of vitamin D on inherent and acquired immune systems are supposed
to reduce inflammation, promote immunological tolerance and increase the intestinal epithelial integrity. Thus this
study was designed to determine the effects of vitamin D supplementation on TNF-α, serum hs-CRP and NF-κB in
patients with UC.
Materials & Methods: In this randomized, double-blind, placebo-controlled study, 50 patients with UC were
divided into two groups which the case group received two pearls of vitamin D (2000IU) once/day for 12 weeks and
the control group received one placebo capsule and one pearl of vitamin D (1000IU) per day. Serum inflammatory
markers, serum hs-CRP and NF-κB were assessed at baseline and the end of the study. Dietary intake and physical
activity of patients is assessed by a valid questionnaire. Anthropometric and diet measurements were assessed in this
study. The SPSS was used for data analysis.
Results: In this study, 24 patients in case group and 22 in control group. Among 50 participants completed the
intervention. At the beginning of study, no significant differences were seen in baseline variables between two
groups. At the end of 12 weeks there were no significant differences in serum hs-CRP, TNF-α between the case and
control group after adjustment for confounders. The level of NF-κB in both groups increased, but this increase in
the low dose group was statistically significant at the end of the study comparing to the beginning (P value=0.006).
Conclusion: Supplementation with 2000IU vitamin D daily for 12 weeks made no changes in serum hs-CRP. Serum
TNF-α, remained with no change in both groups after adjustment. We recommend supplementation of vitamin D
with appropriate dosage in all patients with UC in order to take advantage of its great therapeutic benefits.
J Gastrointest Dig Syst 2019, Volume 09