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Volume 09

Journal of Gastrointestinal & Digestive System

ISSN: 2161-069X

Gastro Congress 2019

July 08-09, 2019

July 08-09, 2019 | Zurich, Switzerland

Euro-Global Gastroenterology Conference

Study of the gut enterotypes in some Egyptian patients with Type 1 diabetes mellitus

Amany Ahmed Elbanna, Shwikar M Abdel Salam Ahmed, Kamel Hemida Rohoma, Ahmed Ismail Ellakany

and

Moamen Ayman Fawzy

Alexandria University, Egypt

Introduction:

Gut microbiota cluster into three enterotypes named the

Bacteroides, Prevotella

and

Ruminococcus

While each person’s microbial “fingerprint” is unique, there are specific patterns seen in those that are healthy and

those that have specific illnesses.

Objective:

The objective of the present study was to identify the enterotypes that are possibly associated with Type I

Diabetes Mellitus (T1DM) Egyptian patients as well as their possible role in the course of the disease.

Subjects & Methods:

The study included 40 T1DM patients as well as control group of 20 healthy subjects of

matched age and sex. Stool specimens were taken from each. Quantitative SYBR Green Real-Time PCR was done

for the identification and quantitation of

Bacteroides, Prevotella

and

Ruminococcus

which constitute the core of the

three major enterotypes.

Results:

Enterotype 1 was the most common enterotype detected in T1DM and control cases (75% versus 65%

respectively) with no significant differences between the two groups (P=0.418). Regarding enterotype 2 no significant

differences was noted between T1DM patients and control group (25% vs. 35% respectively P=0.324). For enterotype

3, it was detected neither in patients with T1DM nor in control cases.

Conclusion:

There was no significant difference in the distribution of enterotypes in all study groups. Therefore,

collapsing the whole microbiome variations into dominant enterotypes was not appropriate to identify disease

association or to be used as a disease biomarker.

J Gastrointest Dig Syst 2019, Volume 09