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Volume 8 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X Gastro Congress 2018
August 20-21, 2018
August 20-21, 2018 | Rome, Italy
13th Euro-Global
Gastroenterology Conference
The relationship between Rh andABO Blood Groups distribution and the incidence of gastric cancer
and peptic ulcer disease: Case-control study
Ziad Aljarad, Ahmad Alhamid, Bashir Badawi Mobayed
University of Aleppo, Syria
Statement of the Problem: In 1953, Aird et al. found an association between blood group A and gastric cancer, and between
blood group O and peptic ulcer disease (PUD). Further research demonstrated relationships between ABO blood groups and
some diseases. No studies included Rh blood groups in the analysis. There is a controversy among studies investigating the
association of ABO blood groups with gastric cancer and PUD. This study aims to investigate the relationship between Rh and
ABO blood groups and the incidence of gastric cancer and PUD. To our knowledge, this is the first study that includes Rh
blood groups in the investigation.
Methodology: We chose case-control design. Participants underwent esophagogastro - duodenoscopy (EGD) during 2016
and 2017 in Aleppo University hospital. We did ABO and Rh typing for all participants. Biopsies were done when indicated.
We formed four case groups: benign PUD group (n=276), benign gastric ulcer group (n=125), benign duodenal ulcer group
(n=169), gastric cancer group (n=26). The control group (n=276) consisted of participants whose EGDs were normal or
revealed only gastritis or duodenitis. We used ODDs Ratio with 95% confidence interval and P-value to evaluate statistical
significance of differences between groups.
Findings: There is no significant relationship between Rh blood groups and gastric cancer or PUD. There is no relationship
between ABO blood groups and PUD. There is an increased risk of gastric cancer among blood group A. Non-A groups
revealed no significant risk. 100% of biopsies showed H. pylori.
Conclusion: After comparing our findings to available literature, we suggest larger-scale studies to investigate the association
of non-A groups with gastric cancer, and Rh groups with gastric cancer and PUD. We recommend studying the feasibility
of establishing screening programs for gastric cancer in people with blood group A. We should determine the prevalence of
H.pylori infection in Syria.
Recent Publications:
1. Manal K. Abdulridha. "The Relationship between ABO Blood Group Distribution and the incidence of Upper Gastric
and Duodenal Ulcer in Iraqi Patients" Iraqi J Pharm Sci, Vol. 22(1) 2013.
2. Zhiwei Wang, ABO Blood Group System and Gastric Cancer: A Case-Control Study and Meta- Analysis, Int. J. Mol.
Sci. 2012, 13, 13308-1332.
3. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer
risk. Crit Rev Clin Lab Sci 2012; 49: 137-49.
4. Edgren, G.; Hjalgrim, H.; Rostgaard, K.; Norda, R.; Wikman, A.; Melbye, M.; Nyren, O. Risk of gastric cancer and
peptic ulcers in relation to ABO blood type: A cohort study. Am. J. Epidemiol. 2010, 172, 1280–1285.
5. A.I. Sharara a, H. Abdul-Baki, ElHajj, Association of gastroduodenal disease phenotype with ABO blood group and
Helicobacter pylori virulence-specific serotypes. Digestive and Liver Disease 38 (2006) 829–833.
Biography
Ziad Aljarad has a master degree in gastroenterology and Hepatology from Aleppo University. He is interested in clinical research. He has four published research
papers and a published book. He is also interested in teaching principles of clinical research to medical students. He has participated in many research activities
and conferences, and he is a member of Continuous Medical Learning and Research Center (CMERC) in Aleppo University. He is also interested in Humanitarian
work. He was the coordinator of health care in the Syrian Arab Red Crescent- Aleppo Branch, and now he is the National Professional Officer for TB, HIV and
Hepatitis in the World Health Organization (WHO).
Ziad Aljarad et al., J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C5-076