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Volume 8 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X Gastro Congress 2018
August 20-21, 2018
Page 61
conferenceseries.com
August 20-21, 2018 | Rome, Italy
13th Euro-Global
Gastroenterology Conference
Raihan A S M A, J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C5-076
Association of Helicobacter pylori and anaemia
Background: Helicobacter pylori (H. pylori) associated gastritis may cause iron deficiency anaemia. Therefore, this infection should
be diagnosed and cured.
Aim: This study is aimed to find out association of H. pylori infection and iron deficiency anaemia.
Methods: Association of H. pylori infection and anaemia was studied in dyspeptic patients. Those who were found to be normal at
upper GI endoscopy were included in this study. Rapid urease test was done to detect H. pylori infection. H. pylori positive patients
were considered as group A and H. pylori negative as group B. A total of 194 patients (aged 18 to 60 years) of both sexes were included,
134 belonged to group A and 60 to group B. Five ml of blood was collected from each patients for estimation of hemoglobin level,
serum ferritin, mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV). Iron deficiency anaemia was defined as
hemoglobin(Hb) concentration <120 g/L in men and <110 g/L in women, serum ferritin <12 μg/L, mean corpuscular haemoglobin
(MCH) <27 pg, and mean corpuscular volume (MCV) <80 fL. Iron deficiency was considered when serum ferritin was <12 μg/L (70).
Results &Conclusions: Serum ferritin was higher in H. pylori negative group than H. pylori positive group. In the multiple regression
model H. pylori infection was associated with 28.8% decrease of serum ferritin (95% CI=-4.85 to-9.1); r2=0.271). The mean MCV
was found to be 85.45±6.93 (in fL) in group A and 88.73±4.58 ( in fL) group B. The difference was statistically significant (p<0.05).
The mean MCH was significantly lower in group A than group B. In male patients, the mean Hb% was lower than group B and the
difference was statistically significant (p<0.05). In female patients mean Hb% of both groups were almost similar. So it appears that H.
pylori infection is associated with iron deficiency anaemia.
Recent Publications:
1. Yip R et al. (1997) Pervasive occult gastrointestinal bleeding in an Alaska native population with prevalent iron
deficiency: role of Helicobacter pylori gastritis. JAMA. 277(14):1135-1139.
2. Marignani M et al. (1997) Reversal of long-standing iron deficiency anaemia after eradication of Helicobacter pylori
infection. Scand. J. Gastroenterol. 32(6):617-622.
3. Seo J K, J S Ko and K D Choi (2002) Serum ferritin and Helicobacter pylori infection in children: a sero-epidemiologic
study in Korea. J. Gastroenterol. Hepatol. 17(7):754-757.
4. Sarker S A et al. (2008) Causal relationship of Helicobacter pylori with iron-deficiency anemia or failure of iron
supplementation in children. Gastroenterology. 135(5):1534-1542.
5. Dunn B E, Cohen H and Blaser M J (1997) Helicobacter pylori. Clinical Microbiology Review. 10(4):720-741.
Biography
A S M A Raihan has been working in the department of Gastroenterology, Banga bandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. His research interest is focused in Irritable
bowel syndrome, inflammatory bowel disease, peptic ulcer disease and Helicobacter pylori infection. His important works are profile of ulcerative colitis in Bangladesh, presented in APDW,
2006, profile of patients of Crohn's disease in Bangladesh, Symptomatic overlap in patients with diarrhoea predominant irritable bowel syndrome and microscopic colitis in Bangladeshi
population and histopathological alteration in post infectious irritable bowel syndrome. He developed a clinical scoring system to differentiate difficult to diagnose cases of intestinal
tuberculosis and Crohn’s disease and presented his work inAsia Pacific Digestive Week, Kobe, Japan in 2016. He has got more than 50 publications and he supervised more than 50 theses.
Raihan A S M A
Bangabandhu Sheikh Mujib Medical University, Bangladesh