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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 91
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
Dark purple glutinous rice Var. Luem Pua tea prevents DSS-induced colitis in mice
J Sattayasai1, K Thipart1, N Techataweewan1, W Mawthong 1, A N L Noenplab2 and N Sattayasai3
1Khon Kaen University, Thailand
2Phitsanulok Rice Research Center, Thailand
3University of Phayao, Thailand
Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract which
is associated with increased risk of developing colitis-associated cancer. Although many chemical-induced colitis models
were developed, dextran sulfate sodium (DSS)-induced colitis model was widely used to assess the therapeutic potential of
treatments for IBD. In this study, the effects of aqueous extract of dark purple glutinous rice var. Luem Pua (LP) tea on
DSS-induced colitis were evaluated. Aqueous extract of LP tea was prepared and dose used was expressed as dried weight
of LP tea. Female ICR mice were forced fed with distilled water or LP extract 2 or 5 g/kg/day for seven consecutive days. On
each day, 2 hours after feeding, water containing 2% DSS was supplied to all groups except the control group. DSS-induced
colitis was scored with disease activity index (DAI) and the colon length, represented the severity of inflammatory lesions in
colon, and spleen weight, represented inflammation stage, were evaluated. The results showed that LP extract antagonized the
reduction of the colon length, the increase in DAI and the increase in spleen weight caused by DSS indicated the reduction of
the inflammation by LP extract treatment. Recently, we have shown that LP contains quite high level of cyanidin-3-glucoside
(C3G) with a high antioxidant activity. C3G is one of the active anthocyanin suggested to have benefit in IBD. Our data suggest
that drinking LP tea might have the beneficial effects in preventing and treating colitis and IBD.
Biography
J Sattayasai has completed her PhD from Monash University. She is now an Associate Professor of Pharmacology.
J Sattayasai et al., J Clin Toxicol 2016, 6:6(Suppl)