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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 51
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
Evaluation of the effects of experimental PCB toxication on oxidative and antioxidative status in
central nervous systems tissues and the protective effect of curcumin
Halef Okan Doğan1, Eray Alçiğir2, Begüm Yurdakök2, Kübra Doğan3, Sevil Atasoy2 and Fatma Meriç Yilmaz4
1Cumhuriyet University, Turkey
2Ankara University, Turkey
3Sivas Numune Hospital, Turkey
4Yildirim Beyazit University, Turkey
In this study, we evaluated the effect of prenatal PCB toxication on oxidant and antioxidant status in the central nervous
system (CNS) tissues and the protective effect of curcumin. Animals were divided into a control group and 2 experimental
groups. Group 1 (n=10) was considered as a control group. In group 2 (n=10), we exposed the pregnant rats to PCB mixture. In
group 3, (n=10) we exposed pregnant rat to PCB mixture and curcumin. We measured plasma neuron specific enolase (NSE)
concentrations in all pups. We also measured total antioxidant status (TAS) level and total oxidant status (TOS) level in the
tissue (brain, cerebellum, pons and medulla oblongata) homogenisats of CNS. In this study, the TOS level was found higher
in brain and cerebellum in group 2 and 3 than control group. However, we did not find any change in TOS and TAS level in
medulla oblongata and pons in group 2 and 3. The concentration of NSE was higher in group 2 than control group. We also
found that the use of curcumin had not any effect on the TOS and TAS concentrations. In conclusion; the main effected part of
the central nervous systems are brain and cerebellum in terms of TOS concentrations. We did not find any effect of curcumin
to increase TAS concentrations and decrease the concentration of TOS in brain and cerebellum. Additionally, NSE can be used
as a useful biomarker to determine the damages found in the CNS in case of prenatal PCB toxication.
Biography
Halef Okan Doğan graduated from Ankara Numune Education and Research Hospital as a Clinical Biochemist in 2013. He is a Biochemistry Laboratory Director
in the Cumhuriyet University, School of Medicine. He has published 9 papers in different scientific journals.
Halef Okan Doğan et al., J Clin Toxicol 2016, 6:6(Suppl)