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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 49
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
East Indian sandalwood oil (EISO) alleviates inflammatory and proliferative pathologies of
psoriasis
Manju Sharma1, Corey Levenson2, Ian Clements2, Paul Castella2 and Michael E Cox1
1Vancouver Prostate Centre, Canada
2Santalis Pharmaceuticals, USA
Psoriasis, a chronic inflammatory skin disease marked by hyper-proliferation and aberrant differentiation of keratinocytes,
affects 2-3% of the population in the United States. Research into the pathogenesis of psoriasis has been hampered by
the lack of animal models that accurately reflect the biology of psoriatic phenotype. We have previously reported that EISO
has significant anti-inflammatory properties in skin models. We hypothesized that EISO might provide therapeutic benefit
to psoriasis patients due to its anti-inflammatory and anti-proliferative properties. The clinical relevance of this hypothesis
is supported by interim results from an on-going proof-of-concept Phase 2 clinical trial in which topically applied EISO is
demonstrating to be well tolerated and helpful in alleviating mild tomoderate psoriasis symptoms. We have evaluated the ability
of EISO to affect the psoriatic phenotype using organotypic psoriasis tissue and normal (non-psoriatic) human skin models
fromMatTek Corporation. Treatment of the psoriasis tissue model with EISO reverted psoriatic pathology, as demonstrated by
histologic characterization and expression of keratinocyte proliferation markers, Ki67 and psoriasin. These phenotypic affects
correlated with greatly suppressed production of ENA-78, IL-6, IL-8, MCP-1, GM-CSF and IL-1β. Demonstration of the ability
of EISO to abrogate these psoriasis symptoms in well-characterized in vitro psoriatic tissue models supports the hypothesis that
the clinically observed symptom alleviation is due to suppression of intrinsic tissue inflammation reactions in afflicted lesions.
This study presents systems to further study the underlying mechanisms that cause psoriasis, and to help direct and accelerate
the development of more effective therapies.
Biography
Manju Sharma is an MD and Doctor of Naturopathy working currently as a Scientist at Vancouver Prostate Centre, Vancouver General Hospital, Canada for the
last 10 years. Prior to this, she worked in the Department of Pathology and Lab Medicine, VGH for 10 years on various projects including molecular diagnosis of
tuberculosis, multi-drug resistant tuberculosis, human solid tumors, kidney disorders, medicinal herbal plants like Echinacea which is widely used all over Europe
and North America for the treatment of cough and cold: Active principles and their mode of action on various human viral and bacterial diseases. She has published
over 75 papers in medical journals and has made several presentations in the field of Medicine.
Manju Sharma et al., J Clin Toxicol 2016, 6:6(Suppl)