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conferenceseries
.com
Volume 5, Issue 6(Suppl)
J Infect Dis Ther, an open access journal
ISSN: 2332-0877
Euro Infectious Diseases 2017
September 07-09, 2017
September 07-09, 2017 | Paris, France
Infectious Diseases
6
th
Euro-Global Conference on
Chitosan and silver nanoparticles: Promising antitoxoplasma agents
Maha Gaafar, Mady R F, Diab RG
and
Shalaby Th I
Alexandria University, Egypt
T
oxoplasmosis is a worldwide infection caused by obligate intracellular protozoan parasite which is
Toxoplasma gondii
.
Chitosan and silver nanoparticles were synthesized to be evaluated singly or combined for their antitoxoplasma effects
as prophylaxis and as treatment in the experimental animals. Results were assessed through studying the parasite density,
studying the ultrastructural parasite changes and estimation of serum gamma interferon. Weight of tissue silver was assessed in
different organs. Results showed that silver nanoparticles used singly or combined with chitosan have promising antitoxoplasma
potentials. The animals that received these compounds showed statistically significant decrease in the mean number of the
parasite count in the liver and the spleen, when compared to the corresponding control group. Light microscopic examination
of the peritoneal exudates of animals receiving these compounds showed stoppage of movement and deformity in shape of
the tachyzoites, whereas, by Scanning Electron Microscope, the organisms were mutilated. Moreover, gamma interferon was
increased in the serum of animals receiving these compounds. All values of silver detected in different tissues were within the
safe range. Thus, these nanoparticles proved their effectiveness against the experimental Toxoplasma infection.
Biography
Gaafar M R has her expertise in diagnosis of different parasitic infections in various samples; blood, stool, urine and aspirates using novel and rapid techniques
as enzymatic assays and real-time PCR. Her trials in treatment of the most common infectious diseases based on the use of new and safe lines of treatment as
herbal treatment as well as the use of nanoparticles either natural or metal as anti-parasitic agents.
drmahagaafar@yahoo.comMaha Gaafar et al., J Infect Dis Ther 2017, 5:6(Suppl)
DOI: 10.4172/2332-0877-C1-033