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conferenceseries.com
Volume 8, Issue 2 (Suppl) J Biosens Bioelectron, an open access journal
ISSN: 2155-6210 Euro Biosensors 2017
July 10-11, 2017
July 10-11, 2017 Berlin, Germany
7th Euro Biosensors
and Bioelectronics Conference
An electrical model for silicon-nanowire electrodes in intracellular signal measurement in biological
environments
Alex Hariz and Nasir Mehmood
University of South Australia, Australia
Measurement of small signals originating from ionic activity inside a biological cell known as action potential, poses a great
challenge to biomedical scientists. The electrical signals of the biological cells result from exchange of ions through the cell
membrane. The characteristics of action potentials may reveal a great deal of information about the causes and symptoms of abnormal
cell behavior. Hence, it is imperative to capture high quality action potentials through the use of nano-sensors from within the cell.
Recently, developments in silicon nanowires (SiNW) fabrication techniques have demonstrated a great potential for them to be
used as nano-electrodes. Large-scale assembly and integration of addressable complementary silicon nanowires arrays have been
demonstrated for multiplexed biosensor arrays. The fabrication process resulted in a high-yield, high performance devices arrays for
chemical and biological detection. In this paper, we seek to model the electrical interface that is responsible for recording the biological
signals. We present electrical equivalent circuits that model the boundary between the biological cell and the nanowire electrode.
Impedance measurement curves of nanowires for various sizes of length and diameter have also been presented and discussed in
this paper. The impedance graphs show a hyperbolic dependence of resistance on length and diameter of nanowires. This non-linear
behavior may be mitigated in software algorithms when interpreting the measured cell signals. We believe that the proposed electrical
model will lead to a more accurate characterization of NW biosensor arrays which are now integrated on disposable PCB interfaces.
It will potentially evolve the sensor arrays into a controllable and scalable nanowire biosensor platform for clinical and point-of-care
diagnostic applications in the near future.
Biography
Alex Hariz completed his MS in 1983 and PhD in 1989 in Department of Electrical Engineering at University of Southern California. He then completed his Post-
doctoral Fellow position in Department of Physics at Simon Fraser University in Canada. He joined the University of South Australia in 1992, and is currently a
Senior Lecturer in School of Engineering, teaching courses such as electronic devices, linear electronics, integrated circuits, and MEMS. His research activities
include “Silicon microelectronics, micro-engineering of inertial sensors, micro-optics and fabrication of bio-MEMS sensors for use in biomedical applications”. He is
an Editorial Board Member of Journal of International Decision Technologies.
Alex Hariz et al., J Biosens Bioelectron 2017, 8:2(Suppl)
DOI: 10.4172/2155-6210-C1-033