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Volume 09
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Epilepsy 2019
Parkinsons Congress 2019
August 29-31, 2019
JOINT EVENT
conferenceseries
.com
August 29-31, 2019 Vienna, Austria
&
5
th
International Conference on
Epilepsy & Treatment
5
th
World Congress on
Parkinsons & Huntington Disease
Catechin regulates intracellular calcium concentration and parvalbumin expression in ischemic brain
injury
Phil-Ok Koh, Dong-Ju Park
and
Ju-Bin Kang
Gyeongsang National University, South Korea
C
alcium is an essential factor that involved inmodulation of cellular functions, such as cell differentiation, survival,
and apoptosis. Parvalbumin is a calcium buffering protein that modulates intracellular calcium concentration.
Catechin has an excellent antioxidant property and exerts a neuroprotective effect. This study investigated whether
catechin can regulate parvalbumin expression and intracellular calcium concentration in middle cerebral artery
occlusion (MCAO)-induced cell damage and glutamate toxicity-induced neuronal cell death. Male Sprague-Dawley
rats were treated with vehicle or catechin (50 mg/kg) immediately before MCAO and cerebral cortical tissues were
collected 24 h after MCAO. Catechin alleviated MCAO-induced infarction and neuronal movement deficit. MCAO
induced a decrease of parvalbumin expression in cerebral cortex. However, catechin administration prevented
MCAO-induced a decrease of parvalbumin. Glutamate excitotoxicity dramatically increased the intracellular
calcium concentration in cultured hippocampal cells, whereas catechin attenuated an increase of intracellular
calcium concentration. We observed a reduction of parvalbumin expression in glutamate-exposed cells. Catechin
prevented glutamate-induced this decrease. These findings suggest that catechin exerts a neuroprotective effect
through regulation of intracellular calcium concentration and parvalbumin expression in ischemic brain injury.
Biography
Phil-Ok Koh has completed her PhD at Gyeongsang National University and Postdoctoral studies from University of Maryland at Baltimore, USA. She is the
Professor of College of Veterinary Medicine at Gyeongsang National University. She has published more than 180 papers in reputed journals and has been
serving as an Editorial Board Member of reputed journals.
Phil-Ok Koh et al., J Alzheimers Dis Parkinsonism 2019, Volume 09