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Volume 09
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Epilepsy 2019
Parkinsons Congress 2019
August 29-31, 2019
JOINT EVENT
conferenceseries
.com
August 29-31, 2019 Vienna, Austria
&
5
th
International Conference on
Epilepsy & Treatment
5
th
World Congress on
Parkinsons & Huntington Disease
Superparamagnetic iron oxideeloaded lipid nanocarriers incorporated in thermosensitive in situ gel for
magnetic brain targeting of clonazepam
Nesrine S El Sayed
Cairo University, Egypt
T
he objective of the study was to target clonazepam to the brain through the intranasal olfactory mucosa using
nanolipid carriers loaded with superparamagnetic iron oxide nanoparticles (SPIONs) to allow nanocarrier
guidance and retention with an external magnetic field. For improved delivery, the nanolipid carriers were
incorporated in a thermosensitive mucoadhesive in situ gel. Different nanolipid carriers including solid lipid
nanoparticles and nanostructured lipid carriers (NLC) were prepared and characterized with respect to particle
size, zeta potential, entrapment efficiency, and in vitro release. The NLC composed of 3 solid lipids (Compritol®
888, stearic acid, and glyceryl monostearate) and 2 liquid oils (oleic acid and glyceryl monooleate) showed the
most satisfactory characteristics and was loaded with SPION (NLC/SPION). Both formulae (NLC and NLC/SPION)
were incorporated in an optimized thermosensitive mucoadhesive in situ system composed of 15% pluronic 127
and 0.75% sodium alginate and evaluated for the anticonvulsant action in chemically induced convulsive Swiss
Albino mice. The treatment of animals with NLC/SPION significantly prolonged the onset times for convulsion and
considerably protected the animals from death. One can thus hope for the emergence of a new intranasal treatment
of epilepsy with consequent decrease in peripheral side effects of clonazepam.
J Alzheimers Dis Parkinsonism 2019, Volume 09