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Volume 09
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Epilepsy 2019
Parkinsons Congress 2019
August 29-31, 2019
JOINT EVENT
conferenceseries
.com
August 29-31, 2019 Vienna, Austria
&
5
th
International Conference on
Epilepsy & Treatment
5
th
World Congress on
Parkinsons & Huntington Disease
Effects of omega-3 on cognitive impairment and chemically-induced seizures in wistar rats
Adamu Bello Yakubu
Bauchi State University Gadau, Nigeria
Background:
Epileptic seizures are associated with cognitive dysfunctions and antiepileptic drugs (AEDs) have
failed to achieve complete seizure control in most epilepsy cases especially in intractable epilepsies.
Aim:
Omega-3 may have more efficacious anticonvulsant effects compared with AEDs in the control of seizures and
improving cognitive function.
Methods:
A total of 60 rats divided in to 12-groups of 5 rats each: groups 1 received omega-3 orally, 2 received 0.9%
normal saline orally (1 and 2 for the neurobehavioral assessment), 3 received PTZ, 4 received PTZ + omega-3, 5
received PTZ + diazepam, 6 received PTZ + carbamazepine, 7 received PTZ + sodium-valproate (3, 4, 5, 6, 7 for
PTZ-induced seizures). 8 received strychnine, 9 received strychnine + omega-3, 10 received diazepam + strychnine,
11 received carbamazepine + strychnine, and 12 received sodium-valproate + strychnine (8, 9,10, 11, 12 for the
strychnine-induced seizures). Seizure was induced using 3mg/kg and 80mg/kg of strychnine and PTZ respectively.
Results:
Seizures related activities and cognitive function were assessed using revised Racine‘s scaling and novel
object recognition and discrimination task respectively. The results showed that, omega-3 is protective against
PTZ-induced seizures, but not in strychnine-induced seizures. Efficacy of omega-3 is comparable with that of
Sodium-valproate but significantly lower than that of diazepam and carbamazepine in PTZ-induced seizures, and
sodium-valproate is more efficacious than omega-3 in strychnine-induced seizure. Omega-3 improved novel object
recognition index, and there was increased pyramidal cells of the hippocampus of rats treated with omega-3 for
2-weeks. Conclusion, omega-3 can be used as an anti-epileptic agent, and for improving cognitive performance.
Key words:
seizures, efficacy, cognitive, epilepsy, anti-epileptic, anticonvulsant.
J Alzheimers Dis Parkinsonism 2019, Volume 09