environmental-microbiology-ecology-2018-posters

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Journal of Ecosystem & Ecography | ISSN: 2157-7625 | Volume 8

July 11-12, 2018 | Toronto, Canada

International Conference on

Environmental Microbiology & Microbial Ecology

International Conference on

Ecology, Ecosystems & Conservation Biology

ESKAPE active antibiotics avoiding resistance development

Brice Felden

Rennes University School of Pharmacy, France

nfections caused by bacteria with developed resistance to nearly all antibiotic classes are critically spreading. They represent a major

cause of mortality and morbidity worldwide, and urgently require new compounds into clinical practice. Here we present cyclic

pseudo mimetic antibiotics bactericidal against ESKAPE human multi-resistant clinical isolates and stable in human sera. Modified,

unnatural amino acids are required for stability and antibacterial activity on infected mice. These novel antibiotics trigger bacterial

deformity, induce cell wall dissolution and alter membrane permeability. Two are active against methicillin and vancomycin resistant

Staphylococcus aureus

on a mice sepsis model and also on a skin infection model. Upon prolonged exposure to the antibiotics in-vitro

and in infected mice, multi-resistant S. aureus did not develop resistance. Three-dimensional structures of the lead compound with

and without modified amino-acids provide structural insights on its activity.

J Ecosys Ecograph 2018, Volume 8

DOI: 10.4172/2157-7625-C3-039