digestive-diseases-2016_posters-accepted-abstracts

7 / 19

Volume 6, Issue 8(Suppl) J Gastrointest Dig Syst 2016
ISSN:2161-069X JGDS, an open access journal
Page 62
Digestive Diseases 2016
December 08-09, 2016
conferenceseries.com
Digestive Diseases
December 08-09, 2016 Dubai, UAE
International Conference on
J Gastrointest Dig Syst 2016, 6:8(Suppl)
Neuroendocrine tumors of the rectum
Aftab Khan
Royal Free Hospital, UK
Aim: To investigate the disease profile of neuroendocrine tumours (NET) of the rectum
Methods: Retrospective review of all the cases managed at a tertiary unit.
Results: A total of 57 cases were identified (median age 53 years: IQR 42-67; 61% were males). The median tumor size was 5mm.
Female patient had larger sized tumor compared to males (p 0.01). About 54% of patients presented with rectal bleeding. NETS 1 cm
accounted to 80.6% of the tumors. The frequency of grades low (G1), intermediate (G2) and high (G3) were 63%, 18.5% and 18.5%,
respectively. The Ki-67 staining of ≤2% was 53%, >2-20% was 41.5% and >20% was G3 6%. Tumor > 5mm frequently showed G2 and
G3 Ki67 (Kendall B, p 0.03) staining. Frequently positive markers also included synaptophysin in 49/50 (86%), CD56 30/32 (52.6%)
and chromogranin 25/50 (50%) cases, respectively. Distant metastasis was present in 21% at the time of diagnosis (commonly in G3
NETS; 60%) and developed in 8.8% after curative treatment. Major surgical resection was only indicated in 9 (15.7%) patients. The
median survival was 32 months (95%CI 19.7 – 44.2 months). About 7 patients (12.3%) died because of the disease process, however,
the 5-year DFS and OS were 66% and 21%, respectively.
Conclusions: Rectal NETS are commonly symptomatic with 80% 1 cm in size requiring minimal surgical treatment to achieve cure.
Five-year DFS and OS were independent of tumour size and grading.
Table 1: Clinical features
Age 55 years
(IQR 43 – 67 years)
Gender Male= 35 (61%);
Female = 22 (38%)
Presenting Symptoms
Rectal bleeding 29 (55%)
Incidental 9 (17%)
Bowel habit change 7 (13%)
Abdominal pain 7 (13%)
Bowel obstruction 1 (2%)
Colonoscopy Polyps 48
Tumor 10
Organs affected
Pre-Treatment Mets 7 (12.3%)
Liver 6
Lung 4
Peritoneum 3