digestive-diseases-2016_posters-accepted-abstracts

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Volume 6, Issue 8(Suppl) J Gastrointest Dig Syst 2016
ISSN:2161-069X JGDS, an open access journal
Page 56
Notes:
Digestive Diseases 2016
December 08-09, 2016
conferenceseries.com
Digestive Diseases
December 08-09, 2016 Dubai, UAE
International Conference on
Frequency of Her2/neu expression in colorectal adenocarcinoma: A study from developing South Asian
country
Asma Shabbir, Talat Mirza, Abdullah Bin Khalid and Muhammad Asif Qureshi
Jinnah Sindh Medical University, Pakistan
Background & Purpose: Human Epidermal Growth Factor (Her-2/neu) has strong therapeutic implications in certain cancers like
breast and gastric cancer. Literature on its frequency in colorectal cancer is scarce. In this study, we have investigated the frequency of
Her-2/neu expression in colorectal adenocarcinomas and its association with various clinicopathological variables.
Methods: A total of 95 patients who underwent colonoscopic biopsy or colectomy were studied after institutional ethical approval.
Hematoxylin & eosin (H&E) staining was performed on all the tissue sections. Expression of Her-2/neu was investigated by
immunohistochemistry using α-Her-2 antibody. In order to quantify Her-2/neu expression, three criteria were applied that includes
the pattern of staining, intensity of staining and percentage of tumor cells stained. Furthermore, its association was seen with various
clinicopathological variables including age, gender, histopathological type, grade and stage of the tumor. Data was entered and
analyzed using SPSS version 21. A p-value of <0.05 was considered as significant.
Results: From the total of 95 cases, 75 (78.9%) cases showed Her-2/neu expression. Pattern of Her-2/neu staining was significantly
associated with the grade (p-value=0.030) and type of colorectal cancer (p-value=0.024). We also observed a significant association
between percentage of cells stained and tumor type (p-value=0.006).
Conclusion: Her2/neu is considerably expressed in colorectal adenocarcinoma in Pakistani population. Our findings indicate a
significant strong association of cytoplasmic Her-2/neu expression with low grades and membranous Her-2/neu expression with high
grades of colorectal cancer.
Biography
Asma Shabbir has a passion towards research and is concerned for better prognosis of the illnesses (especially cancer patients). Her primary area of expertise is diagnostic
pathology and also adores to teach the medical students. Her dissertation work involved evaluation of Her-2/neu in gastric and colorectal adenocarcinomas, the basis of
which arised from the use of targeted therapy (α-Her-2) in breast cancer patients. Similarly, α-Her-2 therapy in gastric and colorectal cancer might give another treatment
option for better prognosis to these patients in this new era of personalized medicine.
Asma Shabbir et al., J Gastrointest Dig Syst 2016, 6:8(Suppl)