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Volume 7, Issue 6 (Suppl) J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460 Dementia 2017
October 16-18, 2017
ALZHEIMER’S DISEASE & DEMENTIA
October 16-18, 2017 | Rome, Italy
9th International Conference on
Microbiological and immunological aspects of Alzheimer's disease
Oleksandr Makarenko1, O Molozhavaya2, T Ivakhnjuk3, I Wolfe4 and R Broz5
1Hrihoriy Skovoroda State Pedagogical University of Pereyaslav-Khmelnitskiy, Ukraine
2Taras Shevchenko National University of Kyiv, Ukraine
3State Medical University of Sumy, Ukraine
4Grant Medical Centre, USA
5Bohomolets National Medical University of Kyiv, Ukraine
Bacteriological and immunological feces study of 28 AD-patients and 60 men 69±1,2 years old as a control group was
conducted. At 28.6±0.6% of AD patients had been showed a significant (p <0.05) reducing the number of anaerobic
representatives microbiota (Bacteroides spp., Fusobacterium spp., Clostridium spp.), quantitative and qualitative changes of
opportunistic microbiota (Klebsiella spp., Proteus spp., Citrobacter spp., Enterococcus spp.) compared with the control group.
The degree of contamination by individual representatives was ≥ 104 CFU/g, which was significantly higher than in control
group. At 42.8±0.7% of AD-patients was found dysbiosis of III degree, significant reduction in the number of obligate anaerobic
microorganisms, decrease in the number of lactobacilli in the range 5.7×103–1.4×104 CFU/g and significant increase in the
degree of intestinal colonization typical opportunistic E.coli. in comparison with the control group, All AD-patients have
diagnostically significant total intestinal colonization by opportunistic microorganisms (>104 CFU/g). At 25,0±1,1% of them
were identified the association of hemolytic Staphylococcus aureus and Candida spp, at 75.0±1.2% – Klebsiella, Hafnia, Serratia,
Proteus, Morganella, Citrobacter.
Biography
Makarenko O M has taken PhD degree at the age of 30 at the Moscow Medical Stomatological Institute, M.D. degree at the age of 40 at the Institute of Higher
Nervous Activity in Moscow. He carries out his post-dock researches at the Institute of higher nervous activity and Taras Shevchenko National University of Kyiv. He
is a professor of the psychology department, the author of more than 200 articles in reputed journals and 5 monographs (Lambert Academic Publishing).
Oleksandr Makarenko et al., J Alzheimers Dis Parkinsonism 2017, 7:6(Suppl)
DOI: 10.4172/2161-0460-C1-033