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conferenceseries
.com
Volume 7, Issue 6 (Suppl)
J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460
Dementia 2017
October 16-18, 2017
ALZHEIMER’S DISEASE & DEMENTIA
October 16-18, 2017 | Rome, Italy
9
th
International Conference on
The study of association between serum brain derived neurotrophic factor protein and dyslipidemia
on memory performance in thai Alzheimer disease patients
Panaree Busarakumtragul
Srinakharinwirot University, Thailand
T
his study aimed to investigate the association between Serum Brain Derived Neurotrophic Factor (BDNF) Protein and
dyslipidemia on memory performance in Thai Alzheimer Disease (AD) patients. It is well known that BDNF protein
has important function in neuronal survival, synaptic plasticity, and neurogenesis in rat hippocampus including learning
and memory. The lower BDNF protein level results in a decrease in synaptic transmission leading to neuronal damage in
hippocampus and neurodegenerative disease in ageing. Moreover, BDNF protein also promotes neurite outgrowth. After
this research project has been approved and certified by human ethic committe Srinakharinwirote University, we recruited
volunteer male and female subjects with aged 45 or more. Before all subjects began to participate in this research, they had to
performThai Mini Mental State Examination (TMMSE). Then thirty subjects were enrolled as control group whereas fifteen
AD patients were participated as experimental group. Then they were withdrawn 10 milliltres of venous blood samples from
left antecubital vein. Blood samples were left at room temperature (25oC) until they become clotted. They were centrifuged
to seperate supernatant for BDNF protein assay by Enzyme Linked Immunosorbent Assay (ELISA) (Milliplex assay kit, Merck
Millipore, Germany). Serum BDNF protein in AD patients was lower and significant different from that in control group at
p<0.05. However, total cholesterol , triglyceride, high density lipoprotein, and low density lipoprotein in AD had no significant
different compared with control group. Furthermore, TMMSE score in AD has significant lower than control group at p<0.05.
We can be concluded that the lower level of serum BDNF protein in AD patients may cause the less scores of TMMSE leading
to reduction in memory performance in Thai AD patients.
Biography
Panaree Busarakumtragul has completed her PhD at the age of 44 years from Mahidol University and she was trained during studying PhD at Seoul National
University, Republic of Korea. She has postdoctoral training from Medical Innsbruck University. She is Associate Dean of Administrative and Academic (Preclinic),
Faculty of Medicine, Srinakharinwirot University. She has been serving as an editorial board member of journal of medicine and health science.
panaree@swu.ac.thPanaree Busarakumtragul, J Alzheimers Dis Parkinsonism 2017, 7:6(Suppl)
DOI: 10.4172/2161-0460-C1-034