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conferenceseries
.com
Volume 7, Issue 6 (Suppl)
J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460
Dementia 2017
October 16-18, 2017
ALZHEIMER’S DISEASE & DEMENTIA
October 16-18, 2017 | Rome, Italy
9
th
International Conference on
Potentials of Gangetin based Phytopharmaceutical formulation Mysgan-2 in management of
Dementia
Hanumanthachar Joshi
and
Majed Mohammed Alkanad & Charan C S
Sarada Vilas College of Pharmacy, India
Background:
Management of cognitive disorders like dementia and Alzheimer’s disease has been challenging since no potential
drug is available with proved efficacy. Some nootropic drugs like piracetam, aniracetam and cholinesterase inhibitors such
as Donepezil® have found to exhibit severe toxic effects in elderly. In Ayurveda, dementia is known as Smutibhransh. In the
present study, phytochemical based formulations with clues from ayurveda and alternative and complementary medicines
were investigated for their efficacy in the management of dementia in animal models relevant to Alzheimer’s disease.
Methods:
Elevated plus Maze, Passive Shock Avoidance and Morris watermaze were the exteroceptive behavioral models.
Scopolamine, ibotenic acid, β-amyloid and ageing induced amnesia were the interoceptive behavioral models.
In vitro
acetylcholinesterase (AChE) and cycloxygenase-1 (COX-1) enzymes activity was also determined. Anti-oxidant activity using
DPPH was assessed.
Results:
MYSGAN-2 significantly improved the transfer latency, stepdown latencies andTSTQwhen testedon exteroceptive and
interoceptive behavioral models. It profoundly improved learning and memory in amnesic mice when tested on interoceptive
behavioral models. The cerebroprotective effect of MYSGAN-2was well supported by photomicrographs of Hippocampus of
brain, where as severity of cell damage, number of pyknotic black neurons, formation of karyorrhexis, karyolysis and number
of neuronal cell death were less comparative to scopolamine, ibotenic acid and β-amyloid treated groups.
Conclusion:
MYSGAN-2 can be useful in restoring memory in the treatment of various types of dementia.
amanjoshi17@yahoo.comHanumanthachar Joshi et al., J Alzheimers Dis Parkinsonism 2017, 7:6(Suppl)
DOI: 10.4172/2161-0460-C1-034