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Volume 7, Issue 6 (Suppl) J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460 Dementia 2017
October 16-18, 2017
ALZHEIMER’S DISEASE & DEMENTIA
October 16-18, 2017 | Rome, Italy
9th International Conference on
In vivo studies to assess the protective influence of Lactobacillus plantarum MTCC1325 onAlzheimer’s
disease
Mallikarjuna Nimgampalle and Yellamma Kuna
Sri Venkateswara University, India
The present investigation was aimed to assess the protective effect of Lactobacillus plantarum MTCC1325 against
D-Galactose induced Alzheimer’s disease (AD) in male albino rats. Recently, we have demonstrated that L. plantarum
modulates the functions of total ATPases and ameliorates the pathological features of AD. In this study, we have evaluated
the potential antioxidant nature of L. plantarum through in vitro assays (DPPH, NO and H2O2), and then estimated the
antioxidant enzymes (SOD, CAT and GR) and lipid peroxidation levels (MDA) in vivo in selected brain regions such as
hippocampus and cerebral cortex of male albino rats. Further, the alterations in gene expressions (BDNF and AChE) in the
hippocampus of experimental and control group rats were assessed by semi-quantitative PCR. From the obtained results it
was evident that chronic injection of D-Galactose caused significant impairment of oxidative stress, lipid peroxidation and
nerve degeneration in the brain. But the treatment of AD induced rats with L. plantarum for sixty days significantly nullified
all above mentioned impairments as compared to AD-Model group. These research findings highlight the protective effects of
L. plantarum MTCC1325 against D-Galactose induced oxidative stress, nerve degeneration and variations of BDNF and AChE
levels in the AD rat brain.
Biography
Nimgampalle Mallikarjuna completed . (Industrial Microbiology) from Sri Venkateswara University, Tirupati in 2011. Later he worked as Quality Executive
Microbiologist in Heritage Foods India Ltd, (Tirupati Branch) during 2012-13. Since 2013 he is pursuing Ph.D. under the guidance of Prof. K. Yellamma, S.V
University, India. His areas of research are Functional foods, bioactive compounds from Actinomycetes, Probiotics and their therapeutical applications in
neurological disorders.
Mallikarjuna Nimgampalle et al., J Alzheimers Dis Parkinsonism 2017, 7:6(Suppl)
DOI: 10.4172/2161-0460-C1-034