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Clinical Gastroenterology 2016
October 03-05, 2016
Volume 6, Issue 6(Suppl) J Gastrointest Dig Syst
ISSN:2161-069X JGDS, an open access journal
conferenceseries .com
October 03-05, 2016 Toronto, Canada
8th International Conference on
Clinical Gastroenterology & Hepatology
Pochamana Phisalprapa, J Gastrointest Dig Syst 2016, 6:6(Suppl)
Cost-effectiveness analysis of ultrasonography screening for non-alcoholic fatty liver disease in
metabolic syndrome patients
Pochamana Phisalprapa
Mahidol University, Thailand
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) can be early diagnosed by noninvasive ultrasonography.
Currently, there is no cost-effectiveness analysis of ultrasonography screening with intensive weight reduction program in
metabolic syndrome patients. This study aimed to estimate costs and clinical outcomes of such program in Thailand.
Methods: A cost-effectiveness analysis using decision tree and Markov models to estimate lifetime costs and health benefits of
screening program versus no screening based on a cohort of 509 Thai metabolic syndrome patients from the largest university
hospital in Thailand under societal perspective was done. Effectiveness and utility parameters were based on literatures, while
costs and mortality parameters were determined using Thailand database. Costs were presented as year 2014 United States
Dollar (USD) values. The results were reported as incremental cost-effectiveness ratios (ICERs) in USD per quality-adjusted
life year (QALY) gained with discount rate of 3%. A series of sensitivity analyses including a Monte Carlo simulation were
performed to assess the influence of parameter uncertainty on the results.
Results: Ultrasonography screening of 50 years-old metabolic syndrome patients with intensive weight reduction program
was cost-effective with ICERs of 958 USD/QALY gained when compared with no screening. According to willingness-to-pay
of Thailand (4,848 USD/QALY gained), the probability of being cost-effective was 67%. Screening at ages before 45 years was
cost-savings while screening at age between 45-64 years was cost-effective.
Conclusion: For patients with metabolic syndromes, ultrasonography screening for NAFLD with intensive weight reduction
program is a cost-effective program in Thailand. Our findings can be used as part of evidence-informed decision making.
Biography
Pochamana Phisalprapa is a Gastroenterologist and Medical Instructor at Faculty of Medicine Siriraj Hospital, Mahidol University. She has completed her MSc in
Health Economics and Health Care Management at Chulalongkorn University, Thailand. She has published more 10 papers in reputed journals.