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Page 34
Volume 9 Journal of Obesity & Weight Loss Therapy
ISSN: 2165-7904
JOINT EVENT
Childhood Obesity 2019
Diabetes Conference 2019
March 18-19, 2019
&
3rd World Congress on Diabetes and Obesity
12th International Conferences on Childhood Obesity and Nutrition
March 18-19, 2019 | Rome, Italy
Alteration in melatonin profile associated to metabolic impairment in childhood obesity
Martin-Carbonell V1 , Gombert M1, Carrasco-Luna J1, 3, Pin Arboleda2 and Codoñer Franch P1, 4
1Universidad de Valencia, Spain
2Quironsalud Hospital, Valencia, Spain
3Universidad Católica Valencia, Spain
4Hospital Universitario Dr. Peset de Valencia, Spain
Introduction: Circadian rhythms are the changes in biological processes occurring on a daily base, among them,
the reactions involved in the metabolic homeostasis. Melatonin is the main circadian hormone, with increased
levels at night. Impairment in circadian rhythms is evidenced by altered melatonin expression, and in adult age, this
condition is associated to metabolic dysregulations.
Methods: One group of obese children and a control group were constituted based on their BMI percentile for age
and sex. The variations of the main circadian hormone, melatonin are assessed in saliva by immunoassay. Blood
sample is collected for basal biochemistry, complemented with leptin and omentin quantification by immunoassay
with Luminex technology. Life habits are assessed by self-reported questionnaires. Preliminary results on 14 patients
(7 obese and 7 controls).
Results: The children from the obese group displayed poorer metabolic characteristic and increased inflammation
markers: C-reactive protein, Gamma-glutamayl transferase, albumin are altered. In the control group, melatonin in
saliva increased during the evening (+20.46±16.1), whereas in the obese group, the melatonin profile was altered and
globally decreased (-3.05±28.4).
Conclusion: In conclusion obesity seems to be associated with circadian rhythm impairment even at a young age.
The continuation of this study, in association with other studies investigating circadian rhythms and health during
childhood will facilitate the development of life habits prevention campaigns, adapted to the children physiology
and development.
Biography
Martin-Carbonell V is currently pursuing her PhD in Physiology from University of Valencia. She has completed University degree of Nutrition from Valencia
University and Master degree in Pediatric Nutrition fromGranada University. She has received best abstract in the International Health Days, Granada 2017. Title
“Libro de Résumenes-Book of abstracts I Jornadas Internacionales de Actualización del Conocimiento Ciencias de la Salud” ISBN: 978-84-15450-26-9. She got
her abstract certificate for Shorter sleep associated with higher energy intake-Preobe study in 9TM Biannual Early nutrition Project Meeting, Granada, May 2016.
She has volunteered in the 42nd Annual Conference of the International Society for Pediatric and Adolescent Diabetes, Valencia in 2016.
Martin-Carbonell V, J Obes Weight Loss Ther 2019, Volume 9
DOI: 10.4172/2165-7904-C1-090