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Volume 9 Journal of Obesity & Weight Loss Therapy
ISSN: 2165-7904
JOINT EVENT
Childhood Obesity 2019
Diabetes Conference 2019
March 18-19, 2019
&
3rd World Congress on Diabetes and Obesity
12th International Conferences on Childhood Obesity and Nutrition
March 18-19, 2019 | Rome, Italy
Modification of inflammation with probiotic intake in obese children
Marie Gombert
University of Valencia, Spain
Introduction: Low grade inflammation is one of the main characteristic associated to obesity, and participates to the
development of numerous comorbidities. The gut microbiota has been evidenced to interact with the host metabolic
and inflammatory condition. We investigated the effect of an alimentary supplementation of Bifidobacterium
pseudocatenulatum CECT 7765 on different elements of obese children health: gut microbiota global composition,
inflammatory cytokines and cardiometabolic risk factors.
Methods: The study included 48 obese children with insulin resistance. They received dietary recommendations
and a capsule of probiotic (10 CFU) or placebo daily for 13 weeks. Clinical, biochemical and gut microbiome
measurement were made at baseline and at the end of the intervention.
Results: All children displayed body mass index (BMI) improvement consecutive to the intervention. Probiotic
intake impacted gut microbiota, increasing the proportion of Rikenellaceae family, particularly the Alistipes genus.
Regarding metabolic and inflammatory parameters, the children who received the probiotic displayed significant
decrease in circulating high-sensitive C-reactive protein (P=0.026), and monocyte chemoattractant protein-1
(P=0.032) and an increase in high-density lipoprotein cholesterol (P=0.035) and omentin-1 (P=0.023) in comparison
with the children who received the placebo.
Conclusion: The positive impact of the intervention on the BMI of all children reveals the benefits provided by
the dietary changes. By complementing this intervention with the intake of B. pseudocatenulatum CECT 7765,
a modification of the gut microbiota has been obtained, with an increase of bacterial groups associated to lean
phenotypes. In parallel, those children displayed a greater improvement on inflammatory status and metabolic
health. Our results suggest that modulation of gut microbiota with probiotic to be an effective tool to ameliorate
obesity-related alterations in children.
Biography
Marie Gombert has completed her Bachelor degree in Biochemistry from the University of La Rochelle (France) and a Master degree in Digestive Health and
Nutrition from the University of Toulouse, France. She is currently studying childhood obesity, in particular the relationship between circadian rhythms and
metabolism, during her PhD in the laboratory of pediatrics of the University of Valencia, Spain. She is co-author of three reviews related to the topic of her PhD.
Marie Gombert, J Obes Weight Loss Ther 2019, Volume 9
DOI: 10.4172/2165-7904-C1-090