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Volume 9
Journal of Obesity & Weight Loss Therapy
ISSN: 2165-7904
Page 10
March 18-19, 2019 | Rome, Italy
&
JOINT EVENT
3
rd
World Congress on
Diabetes and Obesity
12
th
International Conferences on
Childhood Obesity and Nutrition
Childhood Obesity 2019
Diabetes Conference 2019
March 18-19, 2019
Shota Janjgava, J Obes Weight Loss Ther 2019, Volume 9
DOI: 10.4172/2165-7904-C1-089
Shota Janjgava
National Institute of Endocrinology, Tbilisi, Georgia
Influence of testosterone replacement therapy on metabolic disorders and autonomic diabetic
neuropathy in patient with type 2 diabetes mellitus and Androgen deficiency
Introduction:
Over the past few decades, obesity and Diabetes mellitus has become a global health challenge. Multiple
epidemiological studies have shown that low testosterone levels are associated with and predict the future development of
T2D and the metabolic syndrome.
Aim of study:
The aim of study was to show the influence of testosterone replacement therapy on BMI, HbA1c level,
Diabetic neuropathy, and CV-risk factors - with patient diabetes mellitus and Androgen deficiency.
Materials andMethods:
125 male patient with diabetes mellitus was screened, 85 subjects with 41-65 years and BMI 27,0
– 48,0 kg/m2 were randomized In placebo-controlled study, who underwent a routine physical examination and choose
free testosterone examination. Also for assessment of autonomic diabetic neuropathy was used “Vegetotester” — digital
instrument for vegetative nervous system study. According to the laboratory and clinical condition we divided patients
into two groups. 1) First group treatment group 2) Second group placebo group. In the first group we used diet, physical
activity (Lifestyle intervention implies reduced calorie diet (The reduction of daily calorie intake in 800-1200 calorie,
it was selected individually), patient’s antidiabetic therapy and testosterone replacement therapy (TRT), (testosterone
undecanoate 250 mgr/ml intra- muscular 3 months 1 time). In second group we used diet, physical activity (Lifestyle
intervention implies reduced calorie diet (The reduction of daily calorie intake in 800-1200 calorie, it was selected
individually), patient’s antidiabetic therapy and placebo.
Results:
After six months of treatment we repeated the diagnostic assessments: We had some positive results cholesterol,
triglyceride and LDL levels decreased, and HDL increased both of group but better results was in first group which was
clinically significant. Free testosterone level increased in all groups but the best results was in I group which was clinically
significant where was used of testosterone undecanoate. HbA1c decreased in both group but in I group we had the best
result. BMI decreased in both groups but more reduction was in I group. leptin level after treatment was approximately
same in both groups, but compared best results was achieved in I group, also blood pressure were reduced in both group,
where we found alike results. Also in first group were positive results about autonomic diabetic neuropathy.
Discussion:
Autonomic diabetic neuropathy, Serum testosterone, glycosylated hemoglobin, high-density lipoprotein
cholesterol, triglyceride concentrations, and the BMI, Hypertension improved in both treatment groups after 26 weeks
of treatment. We have shown that testosterone replacement therapy improves insulin resistance and glycemic control in
hypogonadal men with diabetes.