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Volume 9 Journal of Obesity & Weight Loss Therapy
ISSN: 2165-7904
Notes:
Page 9
March 18-19, 2019 | Rome, Italy
&
JOINT EVENT
3rd World Congress on Diabetes and Obesity
12th International Conferences on Childhood Obesity and Nutrition
Childhood Obesity 2019
Diabetes Conference 2019
March 18-19, 2019
Erkan Yilmaz, J Obes Weight Loss Ther 2019, Volume 9
DOI: 10.4172/2165-7904-C1-089
Erkan Yilmaz
Ankara University, Turkey
The role of glutamine transport and metabolism in the insulin resistance and endoplasmic
reticulum stress
Glutamine metabolism in insulin resistance mechanisms are not well understood yet. In some cases glutamine can be
used as fuel, levels of glutamine in tissues and circulation can be effective in the regulation of cellular responsiveness
to insulin and cellular metabolism. We aimed to reveal a possible relationship between glutamine metabolism and
endoplasmic reticulum stress in insulin resistance. Fat and liver tissues of Ob/Ob mice, increased endoplasmic reticulum
stress, increased insulin resistance and decreased glutamine transporter (ASCT2) and glutamine signaling (mTOR, LAT1,
GCN2) observed. Glutamine is an important metabolite in the regulation of energy requirements and cellular hemostasis
in the cell. And in insulin resistance in the process of adaptation to the new use of glutamine as a fuel, one of significant
digits is likely to be.
Biography
Erkan Yilmaz has completed his PhD at the Gazi University and Postdoctoral studies from Harvard School of Public Health. He is Associate Professor at Ankara
University, Biotechnology Institute. He has published 30 papers in reputed journals and more than 6000 citations.