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conferenceseries
.com
Volume 8
Journal of Obesity & Weight Loss Therapy
ISSN: 2165-7904
Childhood Obesity 2018
March 15-16, 2018
March 15-16, 2018 | Barcelona, Spain
11
th
International Conference on
Childhood Obesity and Nutrition
Associations of polymorphisms of
LEPr
and
FTO
genes with food consumption in severely obese
individuals
Jaqueline Driemeyer C Horvath
Universidade Federal do Rio Grande do Sul, Brazil
G
enetic factors play an important role in the pathogenesis of obesity. This study aimed at assessing the associations of
polymorphisms of
LEPr
and
FTO
genes with food consumption in obeses. Thus, a cross-sectional study of 222 obeses,
adult patients was carried out. Two SNPs of LEPr (rs1137101 and rs8179183), and one SNP of FTO (rs9939609) were genotyped
and analyzed. The food consumption was measured through a three-day diet diary; nutrients were calculated using Nutribase
software. We used generalized linear models (GLMz) in SPSS 18.0 to analyze the additive effect of each SNP to caloric intake and
macronutrients. The main effect was based on the interaction LEPr rs1137101 and rs8179183; being the caloric consumption
associated to these genes (p<0.037-GLMz). The mean (±standard deviation) of the caloric intake in the LEPr rs1137101 (AA)
genotype was 2780.2 (±1147.9) kcal/day; while in the LEPr rs8179183 (GC) genotype was 2811.2 (±1012.6) kcal/day. In both
cases, the caloric intake was higher than the other genotypes. Regarding the macronutrients, only protein intake was associated
with the SNPs evaluated (p=0.023-GLMz). Removing SNP rs9939609 of FTO from the model had no impact on the statistical
significance. SNPs of the
LEPr
gene seem to play a potential role in the stratification of obese patients, as they may help to
predict those individuals who are at higher risk for upper calories intake, and, therefore, for poorer outcomes. These findings
have to be confirmed in prospective studies.
nut.jaquelinehorvath@gmail.comJ Obes Weight Loss Ther 2018, Volume 8
DOI: 10.4172/2165-7904-C1-058