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CNS 2016
December 05-07, 2016
Volume 7, Issue 5(Suppl) J Neurol Neurophysiol
ISSN: 2155-9562 JNN, an open access journal
conferenceseries .com
December 05-07, 2016 Dubai, UAE
2nd International Conference on
Central Nervous System Disorders & Therapeutics
Basta KaimAgnieszka et al., J Neurol Neurophysiol 2016, 7:5(Suppl)
Emerging role of brain fractalkine signaling in the behavioral and biochemical disturbances in the
course of depression
Basta Kaim Agnieszka, Budziszewska Bogusława, Slusarczyk Joanna and Chamera Katarzyna
Polish Academy of Sciences, Poland
C urrent data reveal that early adverse life experiences may affect the developmental processes of the brain and can be
involved in the pathogenesis of many psychiatric disorders including depression. It has been highlighted that stress
during pregnancy activates the immune response in the offspring’s central nervous system. Results also show important role
fractalkine (CX3CL1) in the neuron-microglia interactions and consequently in production of pro- and anti-inflammatory
factors in the brain. Therefore, the aim of our study was to examine the impact of prenatal stress as well as the role of fractalkine
(CX3CL1) on the behavioral and biochemical changes in adult rats. Adult 3-months old rats offspring (control and prenatally
stressed), after behavioral verification, received icv injections with exogenous fractalkine. After the treatment, we evaluated
time-dependent effects of fractalkine administration on the behavioral parameters. Moreover, we measured the changes in
the production of pro-inflammatory cytokines in the two structures: Hippocampus and frontal cortex. The obtained data
shows that 7 days after treatment with fractalkine, the behavioral disturbances evoked by prenatal stress procedure were
normalized. Moreover, prenatal stress activates production of pro-inflammatory cytokines in the hippocampus and frontal
cortex. Interestingly, treatment with fractalkine inhibited the expression of these factors mainly in the frontal cortex. Summing
up, our study shows that the changes in fractalkine may play an important role in the pathogenesis of depression. Importantly,
the action of the chemokine is connected with its effect on production of inflammatory factors in the brain.
Biography
Basta Kaim Agnieszka has completed her PhD in 1998 in the Institute of Pharmacology Polish Academy of Sciences in Cracow, Poland. Since 2007, she is the
Head of PhD program at the Institute of Pharmacology, PAS. Since 2014, she is a Professor of neuropsychopharmacology and an Expert of neuroimmunology. She
has published more than 100 papers in reputed journals and has been serving as an Editorial Board Member of repute.