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Journal of Gastrointestinal & Digestive System | ISSN: 2161-069X | Volume: 8
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October 29-30, 2018 | San Francisco, USA
International Conference on
Gastrointestinal Cancer and Therapeutics
4th World Congress on
Digestive & Metabolic Diseases
26th Annual Congress on
Cancer Science and Targeted Therapies
Effects of white bean flour (Phaseolus vulgaris) on intestinal mucosa: Food safety assessment
Patrízia Mello Coelho1, Daniel Silva Sena Bastos2, Patrick Fernandes da Silva3, Silvia Almeida Cardoso4, Leandro Licursi de Oliveira2 and Wendeo
Ferreira da Silveira2
1Instituto Federal de Minas Gerais, Brazil
2Universidade Federal de Viçosa, Brazil
3Faculdade de Medicina de Ribeirão Preto, Brazil
4Universidade Federal de Viçosa, Brazil
Bean (Phaseolus vulgaris) "in natura" supplementation has been indicated for fat burning, reduced appetite, and weight
loss. However, there are reports of risks to health arising from its use. This study evaluated the food safety of white bean
flour as a dietary supplement. Mice were divided into three experimental groups (n=10) and 0.5ml of white bean flour extract
(WBFE) were orally administered daily at two concentrations: Group 1 (2.65g/kg), Group 2 (5.30g/kg) and control (PBS) for
14 days. Half of the animals were euthanized on day 14 to assess acute exposure and half on day 28 to assess lesion recovery.
The small intestine was collected for histological analysis, dosage cytokines (TNF, IFN-γ, IL-12, IL-4, IL-6, IL-10 and MCP-
1), and antioxidant enzymes (CAT, SOD, and MDA). The animals WBFE-treated groups had a decrease in body weight and
glycemia in a dose-dependent manner. There was a reduction in the height of the intestinal villi and an increase in the depth
of the crypts. Animals from group 2 (5.30g/kg WBFE) presented mononuclear inflammatory infiltrate in the intestinal mucosa
and increased MCP-1 and NO. SOD, CAT, and MDA were higher in the treated groups, however, no difference in relation to
control. Animals presented repair their intestinal mucosa, reestablishment of glycemia and the increase of weight gain in the
absence of WBFE. The WBFE showed antinutritional and immunomodulatory effects, therefore, it is not safe as oral dietary
supplementation at the dosages used.
Biography
Wendeo Ferreira da Silveira completes biological sciences course at Santa Marcelina University. He started at Universidade Federal de Viçosa–UFV in 2012.
Ended PhD in 2018. He currently coordinates the immunochemistry and glycobiology laboratory of the same institution. It acts in the areas immunotherapy for
experimental Chagas disease, protein-carbohydrate and protein-protein interaction in infections by intracellular pathogens, identification and characterization of
new lectins, IgY microencapsulation for veterinary use, prospecting of biomolecules with antimicrobial and antiparasitic activity, glycobiology of venoms.
Patrízia Mello Coelho et al., J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C8-086