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conferenceseries
.com
Volume 2, Issue 4 (Suppl)
Breast Can Curr Res, an open access journal
Breast Pathology 2017
August 23-24, 2017
August 23-24, 2017 Toronto, Canada
4
th
World Congress on
Breast Pathology and Cancer Diagnosis
Breast Can Curr Res 2017, 2:4 (Suppl)
DOI: 10.4172/2572-4118-C1-009
Promoter region polymorphisms in
IL-6
and
IL-10
genes can lead to pathogenesis of breast cancer
Nadeem Kizilbash
Northern Border University, KSA
T
his study investigated polymorphisms in the promoter regions of
IL-6
(-174 G>C) and IL-10 (-1082 G>A) genes through
a case-control study. Features like the expression of estrogen and progesterone receptors, involvement of the lymph node,
tumor morphology and tumor grades were observed, for the patient group. For the
IL-6
-174G>C polymorphism, there was
significantly higher frequency of C/C genotype in the patients. Further, the C/C genotype was significantly more prevalent
among the patients who had lymph node involvement. For the IL-10-1082G>A polymorphism, there was no difference in the
distribution of genotypes among the patients and control subjects.
fsd707@gmail.com