13 / 18
Page 67
conferenceseries
.com
Volume 2, Issue 4 (Suppl)
Breast Can Curr Res, an open access journal
Breast Pathology 2017
August 23-24, 2017
August 23-24, 2017 Toronto, Canada
4
th
World Congress on
Breast Pathology and Cancer Diagnosis
Nucleostemin immunohistochemical expression is associated with more aggressive phenotypes of
invasive breast cancer
Manal M Sami
1, 2
, Mahmood Y Hachim
3
, Ibrahim Y Hachim
4
and
Ahmed H Elbarkouky
5, 6
1
Ras Al Khaimah Medical and Health Sciences University, UAE
2
Suez Canal University, Egypt
3
University of Sharjah, UAE
4
McGill University, Canada
5
Al Baraha Hospital, UAE
6
Tanta University, Algeria
C
ancer stem cells (CSCs) are postulated to play significant role in the pathogenesis and progression of breast cancer,
among several other cancers, and might contribute to resistance to chemotherapy and/or radiotherapy. Nucleostemin
(NS) is thought to be a key molecule for stemness, and the clinical impact of NS immunoreactivity in breast cancer can
indicate its actual role and future therapeutic potentials. In the current study, NS immunohistochemistry was performed on
purchased TMA sections of 102 patients in addition to a series of 50 archival specimens of invasive breast cancer diagnosed in
Al Baraha Hospital, Dubai, UAE. Ns expression was predominantly exhibited in patients <50 years (p=0.047), in infiltrating
duct carcinoma, tumors >2 cm (74.8%) (P=0.0005), those with lymph node metastasis (79%) (p=0.018) and stage III tumors
(83%) (p=0.0004). Notably, NS expression was significantly correlated to ER negative (75%) and P53 positive (78%) status.
Moreover, HER2 – enriched tumors significantly displayed the highest NS expression, followed by TNBC, Luminal B and
Luminal A (80%, 73%, 60% and 51% respectively) (p=0.048). In conclusion, the significant correlation between NS expression
and the more aggressive clinicopathological attributes of invasive breast cancer implies that NS may be a potential target for
CSC-associated breast cancer management.
manal@rakmhsu.ac.ae