breast-cancer-2016_posters-accepted-abstracts

Volume 8, Issue 8(Suppl)

J Cancer Sci Ther

ISSN: 1948-5956 JCST, an open access journal

Page 91

Notes:

Breast Cancer Congress 2016

September 19-21, 2016

conferenceseries

.com

Breast Cancer

September 19-21, 2016 Phoenix, USA

World Congress on

Claudin-4 as predictor of response to neo-adjuvant chemotherapy in breast cancer

Mandeep Kaur, Chintamani, Niranjan Kumar, Deepak Diwakar, Manish Kumar Mishra, Ravi Prakash Verma, Mandeep Kaur, Anju Bansal

and

Fouzia

Safdarjung Hospital, India

Background

: Neo-adjuvant chemotherapy (NACT) is an integral part of multi-modality approach in the management of

locally advanced breast cancers (LABC) and is vital to predict response in order to tailor the regimen for a patient. Claudins

are important trans-membrane proteins in the inter-cellular tight junctions. Claudin-3, 4 & 7 are often present in breast tumor

and are occasionally expressed at elevated levels. A prospective clinical study was conducted to assess whether these markers

could serve as reliable predictors of response to NACT in patients with LABC.

Materials &Methods

: 80 LABC patients after complete routine and metastatic work up were subjected to trucut biopsy and the

tissue evaluated, immunohistochemically for claudin-4. Three cycles of NACT were given at three weekly interval & patients

were assessed for clinical response following each cycle. Modified radical mastectomy was performed in all patients three weeks

after the third cycle and specimen was re-evaluated for any change in the claudin-4 expression. The immunohistochemical

response (change in the expression of claudin-4 marker) and the clinical response were correlated.

Results

: A statistically significant correlation was observed between clinical and immunohistochemical response to NACT.

Increase in the expression of claudin-4 indicated poor response to NACT and thus a poor outcome.

Conclusions

: Claudin-4 can be effectively utilized as predictors of response to NACT.

Mandeep Kaur et al., J Cancer Sci Ther 2016, 8:8(Suppl)