breast-cancer-2016_posters-accepted-abstracts

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Volume 8, Issue 8(Suppl) J Cancer Sci Ther
ISSN: 1948-5956 JCST, an open access journal
Page 107
Breast Cancer Congress 2016
September 19-21, 2016
conferenceseries.com
Breast Cancer September 19-21, 2016 Phoenix, USA
2nd World Congress on
J Cancer Sci Ther 2016, 8:8(Suppl)
An investigation of breast cancer risk factors in Pakistani population
Sajid Iqbal1 , Sania Javaid2, Ghausia Masood Gilani2, Nayab Batool rizvi2 , Osman Jaffar3, Abdul Rehman Khawaja4
1Emirates College of Technology, UAE
2University of the Punjab, Pakistan
3Molecular Biology and Genetics Laboratory, UAE
4Jinnah Hospital, Pakistan
Brest cancer is the second most widespread and the utmost common cancer among females population in the world. It has
foremost influence on women health. In 2012, worldwide 1.7 million women were diagnosed with breast cancer However,
deaths from breast cancer account for 1.6% of female deaths every year. It is well acknowledged that not only genetic variation
but also the environmental factors plays vital role in increase of breast cancer risk. The main aim of this study was to determine
the prevalence of breast cancer, also to determine the associated risk factors and to assess the strength of association between
these risk factors with breast cancer among Pakistani women. Due to suitability in examining multiple etiological factors for
a single disease we carried out an observational cross-sectional case-control study for the present research. The study includes
105 breast cancer patients and a group of 105 controls (healthy women). The information on demographic characteristics along
with potential risk factors was collected from both groups by means of a standardized face to face interview. Pearson’s Chi-
square/Fisher’s exact test was applied to find out the association between risk factor and breast cancer risk. Furthermore Logistic
regression analysis was used to measure the strength of association, before and after adjusting for the possible confounding
effect of the other factors. Nearly all the cases had self-detected breast lump and breast screening was not a widespread term.
Delay in referral of the cases was another noteworthy finding. Most frequent age at diagnosis was found as 31-50 years and the
most frequent stage was as 2nd stage. The most common histology was unilateral IDC. In multivariate models, Environmental
area and exposure to X-Ray radiations were found to be significantly associated with breast cancer risk (p = 0.012, 0.03).
While in chi-square association female with a positive family history of breast cancer/ were at higher risk for developing breast
cancer (OR = 1.227, 95% CI = 0.655-2.300). An early age at menarche was found to be a strong risk factor for developing breast
cancer (p=0.014). Age less than 12 years increased the risk 2.551 times and an older age at menarche was associated with a
significant reduction in the risk of breast cancer. Menopausal status and age at last pregnancy was found strong risk factor
of breast cancer in our study (P value<0.05) Overall the findings of our study corporate with the results of other previous
descriptive findings, though there were few regional and demographic differences were obvious. This study provides important
background information for designing detailed studies that aim to improve our understanding of the epidemiology of breast
cancer in the Pakistan.