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conferenceseries
.com
Volume 9
Journal of Biotechnology & Biomaterials
ISSN: 2155-952X
JOINT EVENT
February 28-March 02, 2019 | Berlin, Germany
5
th
International Conference on
Enzymology and Protein Chemistry
&
22
nd
Global Congress on
Biotechnology
Biotechnology 2019
Enzymology 2019
February 28-March 02, 2019
&
Peroxiredoxin I as a candidate biomarker of male fertility
Do Yeal Ryu, Saehan Kang, Won Ki Pang, Won Hee Song, Md. Saidur Rahman
and
Myung Geol Pang
Chung Ang University, Republic of South Korea
C
onventional semen analysis has limitations to predict male fertility in livestock industry. Although several studies have
been performed to overcome the limitation, the current solution to prediction is still unsatisfactory. It is generally accepted
that peroxiredoxin I (PRDX I) have a critical role in the regulation of male fertility. Therefore, the current study was designed
to investigate the correlation between PRDX I and male fertility. PRDX I was examined on spermatozoa collected from
14 individual boars with different litter size (10.3-14.2). 530 saws were artificially inseminated to determine the littersize.
Subsequently, several sperm function were evaluated. Our study showed that there is a significant positive correlation between
littersize and PRDX I (r=0.686 and p = 0.007) as well as hyperactivity (r=0.5769 and p=0.031). Subsequently, the prediction
accuracy of boar fertility was determined by the receiver operating characteristic (ROC) curves. The ROC analysis showed
that PRDX I can predict litter size with overall accuracy 92.86% (sensitivity 90%, specificity 100%, negative predictive value
80%, and positive predictive value 100%). In addition, hyperactivity also showed 80% overall accuracy to predict litter size
(sensitivity 70%, specificity 75%, negative predictive value 50%, and positive predictive value 87.5%). As a biomarker, PRDX
I and hyperactivity are expected to increase pups than average litter size (0.54 and 0.45, respectively). As far we know no
other authors have found the correlation between PRDX I and littersize. Consequently, PRDX I might be the novel candidate
biomarker for diagnosing male fertility and littersize in livestock industry.
ilky6618@gmail.comDo Yeal Ryu et al., J Biotechnol Biomater 2019, Volume 9
DOI: 10.4172/2155-952X-C2-116