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Volume 7, Issue 5 (Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal Biotechnology 2017
November 13-14, 2017
November 13-14, 2017 Osaka, Japan
19th World Congress on
Biotechnology
kLa gas-liquid mass transfer coefficient simulation using CFD in helical ribbon impeller
German Ricardo Gelves-Zambrano1, Lilibeth Caridad Niño López2 and Mariana Peñuela2
1Universidad Francisco de Paula Santander, Colombia
2Universidad de Antioquia, Colombia
In the present study a CFD simulation (Computational Fluid Dynamics) applied to non-newtonian fluids was developed
in order to characterize the gas-liquid mass transfer in a 10 L bioreactor equipped with a helical ribborn impeller. The kLa
mass transfer coefficient was estimated Based on CFD results. The operating conditions chosen were defined by typical settings
used for culturing fungi organism. Turbulence, rotating flow, bubbles breakage and coalescence were simulated by using the
k-e, MRF (Multiple Reference Frame) and PBM approaches, respectively. The numerical results from different operational
conditions are compared by evaluating its effect on kLa. Interested by these simulated results CFD simulations are qualified
as a very promising tool not only for predicting gas-liquid hydrodynamics but also for finding design requirements that must
be implemented to optimize an aerobic bioprocessing useful for non-newtonian applications which are characterized by the
constrain of achieving relatively high stirring conditions and avoiding cellular damage due to hydrodynamic conditions.
J Biotechnol Biomater 2017, 7:5 (Suppl)
DOI: 10.4172/2155-952X-C1-083