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Volume 9 Journal of Biotechnology & Biomaterials
ISSN: 2155-952X Biomaterials 2019
February 25-26, 2019
Page 30
Notes:
conferenceseries.com
February 25-26, 2019 | London, UK
4th Annual Conference and Expo on Biomaterials
Tofik M Nagiev, J Biotechnol Biomater 2019, Volume 9
DOI: 10.4172/2155-952X-C1-111
New approaches to simulation of enzymatic reactions: mimetic catalysis
The area between enzymatic and chemical catalyses, associated with simulation of biochemical processes by their basic parameters,
is accepted as mimetic catalysis. The key aspect of mimetic catalyst is diversity of enzyme and biomimetic function processes, which
principally distinguishes the mimetic model from traditional full simulation. Basing on the analysis of conformities and diversities
of enzymatic and chemical catalysis the general aspects of mimetic catalysis are discussed. Idealized model of biomimetic catalyst
and the exclusive role of the membrane in its structural organization are considered. The most important achievements in the branch
of catalysis are shown, in particular, new approaches to synthesis and study of biomimetic catalase, peroxidase and monooxidases
reactions. The catalysis direction, originated from simulation of biochemical processes, is suggested to call the ‘mimetic catalysis’.
Mimetic catalysis designs a real model (a mimic) which simulates objects and processes of enzymatic catalysis by their basic (but
deficient) characteristics (selectivity, condition mildness, active site action mechanism etc.). Since only definite properties of enzyme
are simulated, it does not pretend to completeness of enzyme description, though optimal parameters by some properties may be
approached. The mimetic model of enzyme helps in synthesizing suitable catalysts using inaccurate and sometimes ambiguous
information. The overwhelming majority of biomimetics operate in liquid. Their activity depends on the origin of solvents, reaction
mixture and cell effects. Gas phase oxidation processes are less dependent on these effects and in the first approximation can be
considered as oxidation under quasi-ideal conditions. It goes without saying that enzymatic reactions do not proceed in gases.
However, it is possible to simulate catalytic functions in the gas phase. However, it is possible to simulate catalytic functions in the gas
phase. This simplifies the decoding of the reaction mechanism, not complicated by factors accompanying the liquid-phase oxidation.
Biography
Tofik Nagiev is a Vice-president of Azerbaijan National Academy of Sciences, Director of Research Center of “Azerbaijan National Encyclopedia” and Department Chief
of Nagiev Institute of Catalysis and Inorganic Chemistry of ANAS. He is a Professor of the Department of the physical and colloid chemistry of Baku State University.
Tofik M Nagiev
Nagiev Institute of Catalysis and Inorganic Chemistry, Azerbaijan