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conferenceseries
.com
Volume 8
Journal of Biotechnology and Biomaterials
ISSN: 2155-952X
Biomaterials 2018
March 05-06, 2018
March 05-06, 2018 | Berlin, Germany
3
rd
Annual Conference and Expo on
Biomaterials
Fabrication of calcium sulfate hemihydrate coated β-tricalcium phosphate through dissolution
precipitation reaction
Eddy Eddy, Akira Tsuchiya, Kanji Tsuru
and
Kunio Ishikawa
Kyushu University, Japan
Introduction:
Previously, we had proposed that beta tricalcium phosphate granular cement (β-TCPGC) is useful to prevent
flowing out of the β-TCP granules from the bone defect. When the β-TCP granules were mixed with acidic calcium phosphate
solution, it set to form interconnected porous structure. Although it seems promising, β-TCP granules need to be mixed with
the acidic calcium phosphate solution. Calcium sulfate hemihydrate (CSH) has self-setting ability by converting to calcium
sulfate dihydrate (CSD) when exposed to water. Furthermore, CSD is the component of Osteoset®, which is a commercially
available as a bone substitute. In this study, we fabricated CSH coated β-TCP granules through dissolution-precipitation
method. This setting ability could inhibit the flowing out of the β-TCP granules from the bone defect.
Experimental Method:
β-TCP granules were immersed in NaHSO4 solution for 1, 3, 5 and 7 days at 70
o
C. The samples
were then heated at 120
o
C for 4 hours. β-TCPGC was prepared by mixing the granules with saline solution at a L/P ratio of
0:3 and identified by XRD and SEM. The mechanical strength of the β-TCPGC was measured as a DTS by universal testing
machine. β-TCPGC was implanted in rabbit femur for 4 weeks and the percentage of newly formed bone was calculated from
histological analysis.
Results:
β-TCP granules immersed in NaHSO4 solution were coated by CSD and CSD became CSH after heating at 120ºC for
4 hours. CSH coated β-TCP granules mixed with saline solution were set and DTS value of β-TCPGC with 75 wt.% of CSH
was 0.8±0.1 MPa. The percentage of newly formed bone of β-TCPGC with 75 wt.% of CSH was 28.7±0.5%. Meanwhile, β-TCP
granules without coating were 19.9±1.1%.
Conclusion:
CSH coated β-TCP were successfully fabricated and formed interconnected porous structure with good
mechanical strength after mixing with saline solution
Figure 1: SEM images of CSH coated β-TCP after mixed with saline solution and formed interconnected porous structure.
Recent publications
1. Fukuda N, Tsuru K, Mori Y and Ishikawa K (2017) Fabrication of self-setting β-tricalcium phosphate granular cement. J
Biomed Mater Res: Part B-App Biomater. 106(2):800-807.
2. Fukuda N, Tsuru K, Mori Y and Ishikawa K (2017) Effect of citric acid on setting reaction and tissue response to β-TCP
granular cement. Biomed Mater. 12(1):15027.
Eddy Eddy et al., J Biotechnol Biomater 2018, Volume 8
DOI: 10.4172/2155-952X-C1-088