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Volume 6, Issue 6(Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
Page 20
Bio Summit & Molecular Biology 2016
October 10-12, 2016
conferenceseries.com
October 10-12, 2016 Dubai, UAE
2nd World Congress on
Bio Summit & Molecular Biology Expo
Renata Pasqualini, J Biotechnol Biomater 2016, 6:6(Suppl)
Ligand-directed targeting and molecular imaging based on vascular zip codes revealed by in vivo phage
display
We have developed in vivo phage display, a functional peptide and antibody screening established in animal models and
later in patients, to isolate homing ligands and enable subsequent identification of tissue-specific receptors. Systematic
implementation of this strategy advanced the construction of a comprehensive map of vascular markers in each organ, tissue
or disease. Indeed, our pioneering discoveries of tissue-specific and angiogenesis-related receptors (vascular "ZIP codes") may
lead to a new ligand-directed pharmacology. Over the last few years our efforts have been focused on characterizing the
vascular diversity associated with individual cancer patients using antibody-based drug discovery in a precision medicine
context and optimizing targeted nanoparticles for drug delivery without off-target toxicity. These new programs represent
fertile ground for discovery and drug development.
Biography
Renata Pasqualini is the Professor of Medicine and Cancer Experimental Therapeutics, Associate Director for Translational Research and Chief of the Division of
Molecular Medicine at the University of New Mexico Comprehensive Cancer Center. She has received her PhD from the Ludwig Institute for Cancer Research and
did Postdoctoral training at Harvard Medical School and at the Burnham Institute in La Jolla, CA. In addition to her activities as the Principal Investigator and Head
of a large research laboratory, first at the University of Texas MD Anderson Cancer Center and presently at the University of New Mexico Health Sciences Center,
she serves as a Board Member, Reviewer and Chair in multiple review panels for the National Institutes of Health, the Department of Defense, the Department
of Energy along with several other American, Asian and European Foundations that support basic and clinical research. She is a Referee for several top journals
featuring cutting edge research and technology and has published over 200 papers.
Renata Pasqualini
University of New Mexico Health Sciences Center, USA