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conferenceseries
.com
Volume 7, Issue 4 (Suppl)
J Biotechnol Biomater, an open access journal
ISSN: 2155-952X
Bio America 2017
October 19-20, 2017
October 19-20, 2017 | New York, USA
18
th
Biotechnology Congress
Mono- and dipeptide derivatives of 17β-Amino-5α-androstan-3β-ol
Nanuli Sh Nadaraia, Nana N Barbakadze
and
Meri L Kakhabrishvili
Tbilisi State Medical University, Georgia
S
aturated and unsaturated 17 β-aminosteroids are used as intermediates to synthesize biologically active derivatives. Peptide analogs
of aminosteroids with various physiological activities such as anti-tumor and anti-arrhythmic have been found, were prepared
by adding amino acids to aminosteroids. Mono- and dipeptide derivatives of 17β-amino-5α-androstan-3β-ol were synthesized by
N-acylation with N-protected amino acids (N-Cbz-L-Ala-Bt, N-Cbz-L-Val-Bt, N-Cbz-L-Phe-Bt and N-Cbz-L-Ala-L-Val-Bt) and
their antiviral activity have been studied. Starting amine, which exhibited anti-arrhythmic activity, was prepared from steroidal
saponin - tigogenin using the method developed by us. To conclude, N-protected (α-aminoacyl) benzotriazoles have been utilized in
the successful N-acylation of steroidal amines. Studies of antiviral activities (NIAID) of synthesized mono- and dipeptide derivatives
did not reveal significant activities
Biography
Nanuli Sh Nadaraia has completed her PhD from Mendeleev Moscow Chemical-Technological Institute. She is a Lead Research Scientist at Tbilisi State Medical University.
Her field of interest is chemistry and synthesis of biologically active compounds. She is the author of more than 40 papers in reputed journals and has presentations at 50
international scientific conferences
nnadaraia@ymail.comNanuli Sh Nadaraia et al., J Biotechnol Biomater 2017, 7:4 (Suppl)
DOI: 10.4172/2155-952X-C1-080