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conferenceseries
.com
Volume 7, Issue 4 (Suppl)
J Biotechnol Biomater, an open access journal
ISSN: 2155-952X
Bio America 2017
October 19-20, 2017
October 19-20, 2017 | New York, USA
18
th
Biotechnology Congress
Electrochemical nanobiosensor on Si3N4 nanowell array electrode
YoungTae Seo
1, 4
, Hak Soo Choi
2
, Jonghan Kim
3
and
HeaYeon Lee
3, 4
1
Queens College City University of New York, Kissena Blvd., Flushing, USA
2
Harvard Medical School, USA
3
Northeastern University, USA
4
Mara Nanotech New York, inc. Queens, USA
I
n order for an electrochemical sensor to be adopted in a wide range of applications such as diagnosis in traditional medical,
pharmaceutical, and healthcare settings, medical diagnosis in non-hospital setting (e.g., self-administered consumer diagnostics
as pregnancy test or blood glucose monitoring), non-medical detection of biological and small molecule detection, companion
diagnostics for pharmaceutical therapeutics; research applications where detection of small molecules are required, and other settings
or circumstances where detection of biological molecules is needed, the electrochemical sensor must be sensitive, selective, easy to
use, and readily available to users (i.e., able to manufacture scalably, in large quantities, and at a low cost). We have reported that
Si3N4 nanowell array (NWA) can enhance electrochemical detection of molecular binding events by controlling the binding sites
of the captured molecules. Here we’ll report an immunosensor based on wafer-scale NWA for electrochemical detection of TNF-α.
In order to develop NWA sensor through the cost-effective combination of high-throughput nanopattern, the NWA electrode was
fabricated on glass wafer by krypton-fluoride (KrF) stepper semiconductor process. Finally, 12,500,000 ea nanowell with a 230 nm
diameter having a pitch ratio (ratio between the diameter of the nanowell openings and the shortest distance between neighboring
nanowells) of approximately 1:1 was fabricated on 4 x 2 mm2 substrate
Biography
YoungTae Seo is currently graduate student at Queens College of the City University of New York, USA.
info@mara-nanotech.comYoungTae Seo et al., J Biotechnol Biomater 2017, 7:4 (Suppl)
DOI: 10.4172/2155-952X-C1-080