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Volume 7 Journal of Infectious Diseases & Therapy
Page 45
Bacterial and Rare Diseases 2019
June 17-18, 2019
June 17-18, 2019 Dubai, UAE
Joint Meeting on
&
2nd Annual Congress on Bacterial, Viral and Infectious Diseases
6th International Conference on Rare Diseases & Orphan Drug
Prashanthi Rayapati, J Infect Dis Ther 2019, Volume 7
The effect of G lucidum on the lifespan of Caenorhabditis elegans modeling Duchenne
muscular dystrophy
Prashanthi Rayapati
Lynbrook High School, USA
Duchenne muscular dystrophy (DMD) is an X chromosome-linked disease characterized by progressive
physical disability, immobility and premature death in affected boys. Underlying the devastating
symptoms of DMD is the loss of dystrophin, a structural protein that connects the extracellular matrix to
the cell cytoskeleton and provides protection against contraction-induced damage in muscle cells, leading to
chronic peripheral inflammation. However, dystrophin is expressed in neurons within specific brain regions,
including the hippocampus, a structure associated with learning and memory formation. Linked to this, a
subset of boys with DMD exhibit progressing cognitive dysfunction, with deficits in verbal, short-term, and
working memory. Furthermore, in the genetically comparable dystrophin-deficient mouse model of DMD,
some, but not all, types of learning and memory are deficient, and specific deficits in synaptogenesis and
channel clustering at synapses has been noted. Little consideration has been given to the cognitive deficits
associated with DMD compared with the research conducted into the peripheral effects of dystrophin
deficiency. Therefore, this review focuses on what is known about the role of full-length dystrophin (Dp427)
in the hippocampal neurons. In this experiment, I hypothesized that 100 ug/ml of G. Lucidum would extend
the lifespan and too much concentration of this herbal medicine would lose its efficacy in treating this disease.
A study was conducted through the reactions and lifespan of Caenorhabditis Elegans exhibiting the lack
of dystrophin to the different concentrations of G. Lucidum . As a result, the effect of G. Lucidum on the
Caenorhabditis Elegans modeling DuchenneMuscular Dystrophy was astonishing as 100 ug/ml of G. Lucidum
helped prolong the lifespan of these nematodes by 20%. This data can be reflected onto the lifespan of humans
with DMD as the 20% increase in lifespan of these nematodes could mean the prolonged life of 6-8 years for
humans. However, too much concentration of G. Lucidum was shown not to affect the life of the worms. The
hypothesized argument was proven correct as the results show the 20% increase of lifespan for the 100 ug/
ml of G. Lucidum concentration and the effect of too much concentration of this herbal method. Moreover,
the use of herbal medicine like G. Lucidum could be a new inexpensive and attainable method of treatment
for those diagnosed with DMD. The importance of dystrophin in learning and memory is assessed, and the
potential importance that inflammatory mediators, which are chronically elevated in dystrophinopathies,
may have on hippocampal function is also evaluated.
Biography
Prashanthi Rayapati is currently pursuing her High School at LYNBROOK HIGH SCHOOL, San Jose, CA. Her Research of interests are
Evolutionary Cell Biology research in gene modifications using DNAmethods, Cognitive Artificial Intelligence modeling of Duchenne Muscular
Dystrophy using the C.elegans effect on G.Lucidium on the Life Span of Patients. She got awards like Shri Krupa Volunteer of the Year,
Synopsis Science Fair Honorable Mention, Leukemia and Lymphoma Society Award, JEENA recognition Award.