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conferenceseries
.com
Volume 10
Journal of Carcinogenesis & Mutagenesis: Open Access
Asia Pacific Oncologists & Hospice 2019
May 13-14, 2019
May 13-14, 2019 Singapore
Annual Meeting on
Asia Pacific Oncologists, Hospice and Palliative Care
J Carcinog Mutagen 2019, Volume 10
DOI: 10.4172/2157-2518-C1-006
Achievement of pathologic complete response of patients with locally advanced rectal
adenocarcinoma: A five-year single institution experience in Cebu, Philippines
Dawn Lynn Guardiario
Philippine College of Physicians, Philippines
Background:
The current standard of treatment for locally advanced rectal carcinoma is neo-adjuvant chemoradiation followed
by surgery. However, there is a limited data available on the histopathologic resultant tumor response in the Philippines. This
study reports the achievement of pathologic Complete Response (pCR) of neoadjuvant chemoradiation in patients with locally
advanced rectal cancer in a tertiary institution in Cebu, Philippines.
Method:
This is a retrospective cohort study of 25 adult Filipino patients diagnosed with locally advanced rectal carcinoma
who underwent neoadjuvant chemoradiation followed by surgery at a tertiary hospital in Cebu, Philippines from January 2013
to December 2017.
Results:
Median age at diagnosis was 63 years old with majority (68%) of patients were males. Seventy-two percent presented
with hematochezia while 18% had altered bowel habits. Forty-four percent of the tumors were located at the proximal rectum,
32% were at the distal and 24% were at the middle. All patients had CT scan of the pelvis as the pre-chemoradiation imaging
and they had stage III (T3N1M0) at diagnosis. All patients received neoadjuvant chemotherapy with Capecitabine and
completed the neoadjuvant radiotherapy with total dose of 50.4 Gy for 30-35 sessions in an average of four to five weeks. 88%
of the patients had low anterior resection, 8% had abdominoperineal resection and 4% had proctectomy. In this study, 24% of
patients (6 of 25) achieved a pathologic complete response to neoadjuvant chemoradiation therapy.
Conclusion:
Adult Filipino patients with locally advanced rectal carcinoma treated with neoadjuvant chemoradiation therapy
in a tertiary hospital in Cebu, Philippines were able to achieve a pathologic complete response that is comparable with
internationally published data.
drdawnguardiario@gmail.com