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conferenceseries.com
Volume 10 Journal of Carcinogenesis & Mutagenesis: Open Access Asia Pacific Oncologists & Hospice 2019
May 13-14, 2019
May 13-14, 2019 Singapore
Annual Meeting on
Asia Pacific Oncologists, Hospice and Palliative Care
Eunju Park, J Carcinog Mutagen 2019, Volume 10
DOI: 10.4172/2157-2518-C1-006
Feasibilityof earlyapplicationof anadvancedirective at the time of first-linepalliative chemotherapy
in patients with incurable cancer: a prospective study
Eunju Park
Pusan National University Yangsan Hospital, South Korea
The purpose of this study was to evaluate the feasibility of anAdvance Directive (AD) at the time of starting first-line palliative
chemotherapy. We investigated the changes in emotional distress, Quality of Life (QoL) and attitudes toward anticancer
treatments before and after the AD. Patients with advanced cancer who had just started first-line palliative chemotherapy were
prospectively enrolled between February 2014 and October 2016. We assessed the attitude towards chemotherapy, the Hospital
Anxiety and Depression Scale (HADS) and the European Organization for the Research and Treatment of Cancer Quality of
Life questionnaire (EORTC-QLQ) scores before conducting the AD and subsequently performed the AD after the first cycle
of chemotherapy. Follow-up evaluations using the same parameters were performed in the next cycle visit. During the study
period, 104 patients started palliative chemotherapy. Among them, 41 patients were excluded and the remaining 64 patients
were recommended an AD. Among these 64 patients, 44 agreed to conducting the AD. Ultimately, 41 patients completed the
AD and all data including follow-up, whereas three were excluded. There were no significant differences before and after the
AD in terms of HADS and EORTC-QLQ scores. Attitudes regarding chemotherapy were also unchanged (P=0.773). A total of
36 patients (82%) followed physician recommendations, with the exception of eight patients, who terminated chemotherapy
due to refusal or loss to follow-up. Based on our results showing no significant changes in depression and anxiety scores,
QoL, and attitudes toward anticancer treatments after the AD, early integration of the AD at the start of first-line palliative
chemotherapy is recommended.
Biography
Eunju Park is a Clinical Assistant Professor at the Department of Family Medicine at Pusan National University, Yangsan Hospital in South Korea. Eunju Park is
a clinical assistant professor at the department of family medicine at Pusan National University Yangsan Hospital in South Korea. She is under a PhD at Pusan
national university now.