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Volume 10
Journal of Carcinogenesis & Mutagenesis: Open Access
Asia Pacific Oncologists & Hospice 2019
May 13-14, 2019
May 13-14, 2019 Singapore
Annual Meeting on
Asia Pacific Oncologists, Hospice and Palliative Care
J Carcinog Mutagen 2019, Volume 10
DOI: 10.4172/2157-2518-C1-006
Preoperative prediction of postoperative pancreatic fistula after pancreaticoduodenectomy at
tertiary care center in Nepal
Surendra Shah
1
, Ghimire B
2
and Singh YP
2
1
Patan Hospital- Patan Academy of Health Sciences, India
2
Tribhuvan University Teaching Hospital-Institute of Medicine, India
Introduction:
Post-Operative Pancreatic Fistula (POPF) is a single most common and most significant cause of post-operative
morbidity and perioperative mortality. This study was evaluated the predictive value of Pancreatic Configuration Index (PCI)
to predict POPF after Pancreaticoduodenectomy (PD) at Tribhuvan University Teaching Hospital (TUTH).
Methods:
This was a prospective observational study fromMarch 2017 to June 2018. The patients with age <16 years and those
who underwent re-exploration or mortality before 3
rd
POD, additional surgery along with PD were excluded from the study.
PCI was defined as ratio of pancreatic parenchymal thickness and pancreatic duct diameter (mm) measured in axial CT scan
(pancreatic protocol) of abdomen. Predictive value of PCI in predicting POPF was evaluated.
Results:
Among 58 patients, 9 were excluded from study and 49 patients included in the study. The mean age of the patients was
56.6±13.9 years (21 to 79 years) and male to female ratio was 1.1:1 (26 vs. 23). POPF was developed in 13/49 (26.5%) patients.
On univariate analysis, pancreatic texture (p=0.022), main pancreatic duct diameter at neck (p=0.002) and PCI (p=0.000) were
significantly correlated with the development of POPF which were also significantly correlated with POPF in multivariate
analysis. The sensitivity and specificity of PCI to predict POPF is 92.3% and 91.7% with positive predictive value 80% and
negative predictive value 97.1% respectively.
Conclusion:
Pancreatic configuration index can predict POPF.
drsurendrashah@gmail.com