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Addiction Therapy 2016
October 03-05, 2016
Volume 7, Issue 5(Suppl) J Addict Res Ther
ISSN:2155-6105 JART, an open access journal
conferenceseries .com
October 03-05, 2016 Atlanta, USA
5th International Conference and Exhibition on
Addiction Research & Therapy
Thersilla Oberbarnscheidt et al., J Addict Res Ther 2016, 7:5(Suppl)
Mechanisms of pain and opioid pharmacology
Thersilla Oberbarnscheidt1 and Norman S. Miller2
1Michigan University, USA
2University of Florida, USA
Opioid-induced hyperalgesia (OIH) is a very common consequence of pain management with opioids. Characteristics of
OIH are worsening pain over time despite an increased dose of the opioid. It is often recognized neither by the physician
nor the patient, and it results in increasing doses of opioid medications and continued unsatisfying pain levels experienced
by the patient. The increased use of narcotics has a negative impact on patient outcome, as patients suffer from increased pain
levels and often develop depression. Patients with OIH require frequent assessment for aberrant behaviors as an indicator of
addictive use. Opioid-seeking behavior may complicate the clinical picture of failed opioid therapy. The treatment of OIH is
to discontinue the opioid medication and to treat the patient’s withdrawal symptoms, if necessary, in an inpatient setting with
medical monitoring.
Biography
Thersilla Oberbarnscheidt is a resident psychiatrist at Central Michigan University, Department of Psychiatry, College of Medicine, MI, USA. Thersilla got her
medical degree from the Christian-Albrechts-University in Kiel, Germany and did her 4th Year medical training at Yale University, School of Medicine in New Haven,
CT, USA. She received her PhD in Neuroscience from the Christian Albrechts- University in Kiel, Germany. Her thesis was on Phenazone in the treatment of the
acute migraine attack. Cephalalgia. Efficacy of phenazone in the treatment of acute migraine attacks: a double-blind, placebo-controlled, randomized study.