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Addiction Therapy 2016
October 03-05, 2016
Volume 7, Issue 5(Suppl) J Addict Res Ther
ISSN:2155-6105 JART, an open access journal
conferenceseries .com
October 03-05, 2016 Atlanta, USA
5th International Conference and Exhibition on
Addiction Research & Therapy
Namita Saini Singh, J Addict Res Ther 2016, 7:5(Suppl)
White matter structural damage results in memory decline and impaired visual information processing in
abstinent chronic alcoholics as seen on DTI
Namita Saini Singh
Nuclear Medicine and Allied Sciences, India
C hronic alcohol abuse is characterized by impaired cognitive abilities with a more severe deficit in visual than in verbal
function.
Using DTI we found evidence of microstructural deficits in abstinent alcoholic men in white matter tracts of the right
hemisphere. We found inverse correlation of FA with memory dysfunction scores in white matter tracts associated with reward
circuitry suggesting that white matter deficit could contribute to memory decline in chronic alcoholics.
Neuropsychological tests to assess visual processing skills and deficits were correlated with Fractional Anisotropy and
Mean Diffusivity in the inferior and superior fronto-occipital fasciculus. We found reduced FA and increased MD in these
tracts. FA showed an inverse correlation while MD showed a direct correlation with neuropsychological tests.
Further spectroscopy studies at our centre also showed a significant increase in Cho/Cr and myo-inositol /creatine ratios
while NAA/Cr and Glutamate-Glutamine/Creatine were significantly decreased. The results suggest that metabolic alterations
in the primary visual cortex may contribute to neuropsychological impairment in visual information processing.
Biography
Namita Singh now working as Scientist ‘E’ at Institute of Nuclear Medicine and Allied Sciences (INMAS), Delhi. She earned her MBBS degree from Lady Hardinge
Medical College, Delhi University, India in 1990. She has done her MD in Radio-diagnosis from Delhi University in 1999. She had served with Indian Army Medical
Corps from 1992 to 2002 and joined INMAS in 2004 where she is working in the NMR Department housing a 3T MRI from Siemens (Skyra). Her current interest
involves studying cognitive impairment in alcoholic subjects, HIV positive subjects using advanced MR imaging t.echniques. She has also conducted research on
spinal tuberculosis using DTI.