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Volume 4, Issue 4(Suppl) J Infect Dis Ther 2016
ISSN: 2332-0877, JIDT an open access journal
Page 38
Notes:
Infectious Diseases 2016
August 24-26, 2016
conferenceseries.com
August 24-26, 2016 Philadelphia, USA
&
Infectious DiseasesJoint Event on 2nd World Congress on
Pediatric Care & Pediatric Infectious Diseases
International Conference on
Antibody level against malaria and the added effect of intestinal parasites
Amanuel Ateweberhan Woldemariam
Huazhong University of Science and Technology, China
Immune response to malaria and intestinal parasites is characterized by antibody production (IgE). Th2 immune response gives
rise to antibody production and in this study the serum antibody level has been quantified in malaria patients with and without
additional intestinal parasitic infection. The study was composed of 198 malaria positive and 217 malaria negative apparently healthy
controls. Patients can be with or without additional intestinal parasitic infection. It was a cross sectional observational study conducted
at Keren Hospital, Eritrea, Northeast Africa. A pre-designed structured format was utilized to collect socio-demographic and clinical
data of the subjects. Detection and quantification of intestinal parasites, malaria parasites and quantification of serum antibody levels
were done following standard procedures. Antibody levels of malaria-positive patients were significantly high as compared to that of
malaria free apparently healthy controls (with and without intestinal parasitic infections). Malaria-positive patients with additional
intestinal parasitic infection showed high level of antibody (2199 IU/ml) compared with those malaria patients without intestinal
parasites (1669 IU/ml). The association between malaria parasitic density and level of antibody was highly significant (P=0.001) with
2048 IU/ml in high parasitaemia and 1779 IU/ml in low parasitaemia. Intestinal parasite egg loads were also significantly associated
with level of antibody (P=0.003). It can be concluded that the level of antibody increases in response to malaria. It also increases
in response to intestinal parasites. When compared, malaria infection is stronger than intestinal parasitic infection in driving the
production of the antibody. Moreover, antibody level is correlated with malaria parasite density and intestinal parasite egg loads.
Biography
Amanuel Ateweberhan Woldemariaman is an Assistant Lecturer in Orotta School of Medicine, Asmara, Eritrea. He has worked in different laboratories in Eritrea, East Africa.
Currently, he is pursuing Masters in Immunology at Huazhong University of Science and Technology, Tongji Medical College, Wuhan, China.
Amanuel Ateweberhan Woldemariam, J Infect Dis Ther 2016, 4:4(Suppl)