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Volume 6 Journal of Child and Adolescent Behavior
October 01-02, 2018 Osaka, Japan
3rd World Congress on
Pediatric Neurology and Pediatric Surgery
Neuropediatrics 2018
October 01-02, 2018
Mozart's music in children with drug-refractory epileptic encephalopathies
Coppola Giangennaro
University of Salerno, Italy
Statement of the Problem: Mozart's sonata for two pianos in D major, K448, has been shown to decrease interictal EEG
discharges and recurrence of clinical seizures in both adults and young patients. In this prospective, open-label study, we
evaluated the effect of listening to Mozart’s K448, according to the Tomatis method, on sleep quality and behavioral disorders,
including auto-/hetero-aggression, irritability and hyperactivity, in a group of children and adolescents with drug-resistant
epilepsy. In a further, prospective, randomized, open label study, the effect on seizure recurrence and quality of life parameters,
of two different protocols of music therapy was compared in the same kind of patients.
Method: During the first study 11 outpatients, aged between 1.5 and 21 years, all suffering from drug-resistant epileptic
encephalopathy associated with a severe/profound intellectual disability and cerebral palsy had to listen to a set of Mozart's
compositions 2 h/day for 15 days for a total of 30 h. In the second trial, 19 patients with epileptic encephalopathies, aged
between 1 and 24 years, were randomized to listen to Mozart’s K448 for 2 h/day for 2 weeks or to a set of Mozart’s compositions
(Mozart’s set).
Findings: In the first study, 2/11 patients had a reduction of 50-75% in seizure recurrence, and 3/11 a decrease of 75-89%.
Overall, 5/11 patients (45.4%) had a ≥50% reduction in the total number of seizures. In the second trial, 22% of the K448 group
had a≥75% seizure decrease, compared with 70% of patients in the Mozart set group.
Conclusion: The present study seems to confirm that music therapy may be an additional, non-pharmacological, effective
treatment for patients with refractory epileptic seizures in childhood. The Mozart’ set of different compositions can be better
accepted and effective than the K448.
J Child Adolesc Behav 2018, Volume 6
DOI: 10.4172/2375-4494-C1-006