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conferenceseries
.com
Volume 05
Neonatal and Pediatric Medicine
ISSN: 2572-4983
World Pediatrics 2019
December 04-05, 2019
December 04-05, 2019 | Barcelona, Spain
32
nd
World Pediatrics Conference
Hemodynamic effects of dobutamine versus dopamine in preterm infants: An update meta-analysis
Li Jiang
Nanjing Medical Universtiyy, China
H
emodynamic effects of dobutamine versus dopamine in preterm infants: an updatemeta-analysis: It is ameta-analysis
to compare the effects and safety of dobutamine versus dopamine in preterm infants with abnormal hemodynamic
status. Study sources were up to 2017 for RCTs in which dobutamine and dopamine treatment was adopted. Included
studies were conducted on preterm infants with abnormal hemodynamic status that reported mortality <28 days,
treatment failure and organ effects. 7 articles were included with a total 286 patients. 5 studies reported mortality (180
patients), 4 studies reported P/IVL (145 patients), 4 studies reported P/IVH (160 patients), 2 studies reported severe P/
IVH (105 patients), 3 studies reported NEC (140 patients), 2 studies reported BPD (55 patients) and 6 studies reported
treatment failure (266 patients). Meta-analysis showed an increased probability in treatment failure using dobutamine
treatment (RR, 1.67; 95% CI, 1.14-2.45; P = 0.008), whereas there was no significant difference in mortality <28 days (RR,
1.16; 95% CI, 0.70– 1.91; P = 0.57), P/IVL (RR, 2.90; 95% CI, 0.93-9.11; P = 0.07), P/IVH (RR, 1.23; 95% CI, 0.73-2.08; P
= 0.44), severe P/IVH (RR, 0.58; 95% CI, 0.21-1.62; P = 0.30), NEC (RR, 2.21; 95% CI, 0.60-8.09; P = 0.23) and BPD (RR,
1.04; 95% CI, 0.38-2.82; P = 0.94) between two groups. Dopamine was more effective in treatment success in therapy of
preterm infants with abnormal systemic hemodynamic status. No difference was found existed in mortality <28 days and
incidence of adverse organ effects in two groups.
Neonat Pediatr Med 2019, Volume: 05